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HomeProduct name listBenzimidazole

Benzimidazole

Synonym(s):1,3-Benzodiazole;Benzimidazole;BZI

  • CAS NO.:51-17-2
  • Empirical Formula: C7H6N2
  • Molecular Weight: 118.14
  • MDL number: MFCD00005585
  • EINECS: 200-081-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:08:52
Benzimidazole Structural

What is Benzimidazole?

Chemical properties

white crystals

The Uses of Benzimidazole

Usually used as template compound in the preparation of molecularly imprinted polymer via electropolymerization and electrodeposition of pyrrole on a pencil graphite electrode,and also used in the preparation of benzimidazolium surfactant, 1-hexadecyl-1H-benzimidazole.

The Uses of Benzimidazole

Benzimidazole is a building block for making anthelmintic drugs like albendazole, mebendazole and triclabendazole and anti-ulcer drugs like pantoprazole, rabeprazole, lansoprazole and omeprazole. It is used in the preparation of pyrene derived benzimidazole linked polymers (BILPs), which are used for selective carbon dioxide separation applications due to their properties like porous materials, regenerability and sorbent selection parameters.

Definition

ChEBI: 1H-benzimidazole is the 1H-tautomer of benzimidazole. It is a benzimidazole and a polycyclic heteroarene. It is a conjugate acid of a benzimidazolide. It is a tautomer of a 4H-benzimidazole, a 2H-benzimidazole and a 3aH-benzimidazole.

General Description

White tabular crystals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

An amine. Neutralizes acids to form salts plus water. These acid-base reactions are exothermic. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. May be shock sensitive.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzimidazole emits highly toxic fumes.

Fire Hazard

Flash point data for Benzimidazole are not available. Benzimidazole is probably combustible.

Pharmacology

The mode of action of benzimidazoles has been described in several comprehensive reviews (1,32,33). The primary mode of action of benzimidazoles has been identified as the specific binding to the β-subunit of fungal tubulin and, consequently, an interference with microtubule assembly. Microtubules are major components of the fungal cytoskeleton and are involved in meiosis and mitosis, both of which are blocked in the presence of benzimidazoles.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits highly toxic fumes of NOx.

Purification Methods

It crystallises from water or aqueous EtOH (charcoal) and is dried at 100o for 12hours. [Beilstein 23 H 131, 23/6 V 196.]

Properties of Benzimidazole

Melting point: 169-171 °C (lit.)
Boiling point: 360 °C
Density  1.1151 (rough estimate)
refractive index  1.5500 (estimate)
Flash point: 360°C
storage temp.  Store below +30°C.
solubility  xylene: soluble1g in 2g (boiling)(lit.)
form  Crystalline Powder or Crystals
pka 5.532(at 25℃)
color  Beige to brown
Water Solubility  sparingly soluble
λmax 271nm(MeOH)(lit.)
Merck  14,1081
BRN  109682
Stability: Stable. Combustible. Incompatible with strong oxidising agents.
CAS DataBase Reference 51-17-2(CAS DataBase Reference)
NIST Chemistry Reference 1H-Benzimidazole(51-17-2)
EPA Substance Registry System Benzimidazole (51-17-2)

Safety information for Benzimidazole

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for Benzimidazole

InChIKey HYZJCKYKOHLVJF-UHFFFAOYSA-N

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