2-Chlorobenzimidazole

CAS NO.：4857-06-1
Empirical Formula: C7H5ClN2
Molecular Weight: 152.58
MDL number: MFCD00051944
EINECS: 225-453-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-29 11:48:30

What is 2-Chlorobenzimidazole?

Chemical properties

BEIGE TO BROWN CRYSTALLINE POWDER

The Uses of 2-Chlorobenzimidazole

2-Chlorobenzimidazole is mainly used for the synthesis of medicine and as an intermediate in organic synthesis.

What are the applications of Application

2-Chlorobenzimidazole can be used to synthesize the following:
1-methyl-2-chlorobenzimidazole via reaction with dimethyl sulfate
1-ethyl-2-chlorobenzimidazole via reaction with diethyl sulfate
1-benzyl-2-chlorobenzimidazole via reaction with benzyl chloride
2-chloro-4,5,6,7-tetrabromobenzimidazole via bromination with bromine
It may be used as a building block to synthesize 4-amino-6-benzimidazole-pyrimidines.

General Description

2-Chlorobenzimidazole can be synthesized by reacting benzimidazole-2-one with phosphoryl chloride in the presence of phenol.

Properties of 2-Chlorobenzimidazole

Melting point:	207-211 °C (lit.)
Boiling point:	250.67°C (rough estimate)
Density	1.2763 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	9.81±0.10(Predicted)
form	Crystalline Powder
color	Beige to brown
Water Solubility	Insoluble in water.
Sensitive	Moisture Sensitive
BRN	116526
CAS DataBase Reference	4857-06-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Chlorobenzimidazole(4857-06-1)
EPA Substance Registry System	1H-Benzimidazole, 2-chloro- (4857-06-1)

Safety information for 2-Chlorobenzimidazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.