Benzilic acid

Synonym(s):Benzilic acid;Diphenylglycolic acid

white powder

Benzilic Acid is an impurity of Trospium (T892800), a tropine derivative with anticholinergic activity and a antiispasmodic agent.

ChEBI: Benzilic acid is a 2-hydroxy monocarboxylic acid.

The Journal of Organic Chemistry, 29, p. 1631, 1964 DOI: 10.1021/jo01029a509

Moderately toxic by subcutaneousroute. Slightly toxic by ingestion. When heated todecomposition it emits acrid smoke and irritating vapors.

Crystallise benzilic acid from *benzene (ca 6mL/g), or hot H2O. [Beilstein 10 IV 1256.]

Melting point:	149-151 °C(lit.)
Boiling point:	180 °C
Density	1.28
refractive index	1.5805 (estimate)
Flash point:	180°C/22mm
storage temp.	Store below +30°C.
solubility	1.41g/l (experimental)
form	Powder
pka	pKa (25°): 3.036
color	White to cream-white
Water Solubility	1.41 g/L (25 ºC)
Merck	14,1080
BRN	521402
Stability:	Stable. Incompatible with strong oxidizing agents. Combustible.
CAS DataBase Reference	76-93-7(CAS DataBase Reference)
NIST Chemistry Reference	Benzeneacetic acid, «alpha»-hydroxy-«alpha»-phenyl-(76-93-7)
EPA Substance Registry System	Benzilic acid (76-93-7)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed.