2,2-Diphenylacetic acid

CAS NO.：117-34-0
Empirical Formula: C14H12O2
Molecular Weight: 212.24
MDL number: MFCD00004251
EINECS: 204-185-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-11 22:00:27

What is 2,2-Diphenylacetic acid?

Chemical properties

white to creamy-white crystalline powder

The Uses of 2,2-Diphenylacetic acid

Kinetic resolution of racemic 1-heteroarylalkanols by asymmetric esterification using diphenylacetic acid with pivalic anhydride and a chiral acyl-transfer catalyst is described. Molecular crystal of acridine and diphenylacetic acid and its absolute asymmetric photodecarboxylating condensation generates chirality in a two-component. The activation parameters for the racemization of a series of ortho-alkyl-substituted diphenylacetic acids are determined.

Definition

ChEBI: A monocarboxylic acid that is acetic acid where the methyl hydrogens have been replaced by two phenyl groups respectively.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 2325, 1947 DOI: 10.1021/ja01202a023
Synthetic Communications, 17, p. 1919, 1987 DOI: 10.1080/00397918708057804

Purification Methods

Crystallise the acid from *benzene, H2O or aqueous 50% EtOH. [Beilstein 9 H 673, 9 IV 2492.]

Properties of 2,2-Diphenylacetic acid

Melting point:	147-149 °C(lit.)
Boiling point:	195°C 25mm
Density	1,257 g/cm³
vapor pressure	0.001Pa at 25℃
refractive index	1.6000 (estimate)
Flash point:	195°C/25mm
storage temp.	Sealed in dry,Room Temperature
solubility	0.13g/l
form	Crystalline Powder
pka	3.94(at 25℃)
color	White to creamy-white
PH	3.8 (H2O, 20℃)(saturated solution)
Water Solubility	Slightly soluble in water(0.13g/L).
Merck	14,3316
BRN	1910978
CAS DataBase Reference	117-34-0(CAS DataBase Reference)
NIST Chemistry Reference	Benzeneacetic acid, «alpha»-phenyl-(117-34-0)
EPA Substance Registry System	Benzeneacetic acid, .alpha.-phenyl- (117-34-0)

Safety information for 2,2-Diphenylacetic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.