BENFLUOREX HYDROCHLORIDE
- CAS NO.:23602-78-0
- Empirical Formula: C19H20F3NO2
- Molecular Weight: 351.36
- MDL number: MFCD00242709
- EINECS: 245-777-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:36
What is BENFLUOREX HYDROCHLORIDE?
Originator
Mediator,Servier,France,1976
The Uses of BENFLUOREX HYDROCHLORIDE
antihyperlipoproteinemic
Definition
ChEBI: Benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester is a benzoate ester.
Manufacturing Process
To a solution of 24.7 parts of 1-(m-trifluoromethylphenyl)-2-(β-
hydroxyethyl)amino propane in 140 parts of anhydrous benzene, there were
added successively 15 parts of 4.7N hydrochloric ether and a solution of 14
parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition
required 10 minutes, the reaction mixture was then refluxed for 8 hours.
The solid product was collected by filtration and after recrystallization from
230 parts of ethyl acetate, there were obtained 15 parts of 1-(mtrifluoromethylphenyl)-
2-(β-benzoyloxyethyl)amino propane hydrochloride
melting at 161°C.
10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts
ether are added, then 10 parts of a concentrated solution of ammonium
hydroxide. The mixture is stirred a few minutes until the salt is dissolved,
then the ethered solution is poured off and dried. After the ether is
eliminated, 9 parts of 1-(m-trifluoromethylphenyl)-2-(β-
benzoyloxyethyl)amino propane are obtained; the base is a colorless oil.
Therapeutic Function
Antihyperlipidemic, Cardiovascular
Properties of BENFLUOREX HYDROCHLORIDE
Boiling point: | 420.5±45.0 °C(Predicted) |
Density | 1.183±0.06 g/cm3(Predicted) |
pka | 8.23±0.10(Predicted) |
Safety information for BENFLUOREX HYDROCHLORIDE
Computed Descriptors for BENFLUOREX HYDROCHLORIDE
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