AZOXYMETHANE

Synonym(s):AOM

CAS NO.：25843-45-2
Empirical Formula: C2H6N2O
Molecular Weight: 74.08
MDL number: MFCD00126912
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:30

What is AZOXYMETHANE?

The Uses of AZOXYMETHANE

Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention.

What are the applications of Application

Azoxymethane is a carcinogen and gene mutation agent used to study cancer progression and prevention.

General Description

Clear oily liquid.

Air & Water Reactions

AZOXYMETHANE is sensitive to prolonged exposure to air and elevated temperatures . Soluble in water.

Reactivity Profile

AZOXYMETHANE is an azo compound. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

Health Hazard

ACUTE/CHRONIC HAZARDS: AZOXYMETHANE is highly flammable and sensitive to elevated temperatures. Upon decomposition it emits toxic fumes.

Fire Hazard

Flash point data for AZOXYMETHANE are not available. AZOXYMETHANE is probably highly flammable.

Biochem/physiol Actions

Carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.

Safety Profile

Suspected carcinogen with experimental carcinogenic and mmorigenic data. Poison by subcutaneous route. An experimental teratogen. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

Properties of AZOXYMETHANE

Boiling point:	97-99 °C (lit.)
Density	0.991 g/mL at 25 °C (lit.)
refractive index	1.4368 (estimate)
Flash point:	24 °C
storage temp.	-20°C
solubility	Soluble in water, ethanol, and ether
form	Liquid
Specific Gravity	0.991
color	Oil
InChI	InChI=1S/C2H6N2O/c1-3-4(2)5/h1-2H3
EPA Substance Registry System	Azoxymethane (25843-45-2)

Safety information for AZOXYMETHANE

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H226:Flammable liquids H300:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H350:Carcinogenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.