Arecoline hydrobromide
Synonym(s):1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester hydrobromide;Arecaidine methyl ester hydrobromide;Methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide;Methyl 1-methyl-1,2,5,6-tetrahydronicotinate hydrobromide;Taeniolin
- CAS NO.：300-08-3
- Empirical Formula: C8H14BrNO2
- Molecular Weight: 236.11
- MDL number: MFCD00039041
- EINECS: 206-087-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-14 17:56:46
What is Arecoline hydrobromide ?
Description
Arecoline (CAS 300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer.? Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1?Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50?in the range of 7-410 nM).2?May be effective in dementia.3
The Uses of Arecoline hydrobromide
Arecoline is a muscarinic acetylcholine receptor agonist. Arecoline induces ADP ribosylation of histones and chromatid relaxation in spleen and bone marrow cells. In a study, a controlled trial involving 122 dogs experimentally infected with Echinococcus
What are the applications of Application
Arecoline hydrobromide is an alkaloid originally extracted from betal nut palm seed
Properties of Arecoline hydrobromide
| Melting point: | 171-175 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| form | Powder |
| color | White to light yellow |
Safety information for Arecoline hydrobromide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Arecoline hydrobromide
| InChIKey | AXOJRQLKMVSHHZ-UHFFFAOYSA-N |
Abamectin manufacturer
JSK Chemicals
New Products
3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Piperidinopiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6 Di acetylpyridine 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-Aminophenaethylalchol 3-NITRO-5-ACETYL IMINODIBENZYL (S)-(+)-4-BENZYL-2-OXAZOLIDINONE 4-FLUORO PHENYL MAGNESIUM BROMIDE 1.0 M IN THF 1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)Related products of tetrahydrofuran
You may like
-
300-08-3 Arecoline hydrobromide, 98% 99%View Details
300-08-3 -
68915-31-1 99%View Details
68915-31-1 -
Azadirachtin 11141-17-6 99%View Details
11141-17-6 -
26062-79-3 99%View Details
26062-79-3 -
Geraniol 99%View Details
106-24-1 -
BENZALKONIUM CHLORIDE BKC 99%View Details
8001-54-5 -
Amrit Neem 11141-17-6 99%View Details
11141-17-6 -
Phosphonobutane Tri Carboxylic Acid 99%View Details
37971-36-1