DEXTROMETHORPHAN HYDROBROMIDE
Synonym(s):(9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide;Dextromethorphan hydrobromide monohydrate
- CAS NO.:125-69-9
- Empirical Formula: C18H26BrNO
- Molecular Weight: 352.31
- MDL number: MFCD00269810
- EINECS: 204-750-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is DEXTROMETHORPHAN HYDROBROMIDE?
Originator
Symptom 1 ,Parke Davis,US,1977
The Uses of DEXTROMETHORPHAN HYDROBROMIDE
It is used as a potentially useful NMDA receptor agonist. it is usually used as central nervous antitussive, cough suppressant. This is one of the most popular ingredients in over-the-counter cold and cough medications. Dextromethorphan hydrobromide may be added to other preparations to help treat pain and a variety of other disturbances as well. It is used as a pharmaceutical raw material.
The Uses of DEXTROMETHORPHAN HYDROBROMIDE
relieving cough
The Uses of DEXTROMETHORPHAN HYDROBROMIDE
Cough and cold preparations, Antitussives, OTC cough medicine
What are the applications of Application
Dextromethorphan Hydrobromide is a potentially useful NMDA receptor agonist
Manufacturing Process
The methylation of 51.4 parts by weight of D,L-3-hydroxy-N-methylmorphinan is carried out with a methylating solution obtained from 51.5 parts
by weight of phenyl-trimethylammonium-chloride. The D,L-3-methoxy-Nmethyl-morphinan is isolated in the form of its hydrobromide, which melts
with 1 mol of water at 92°-94°C,without water at 239°-240°C. The base
isolated from the aqueous solution by means of sodium carbonate melts at
81°-83°C.
27.1 parts by weight of D,L-3-methoxy-N-methyl-morphinan base are
dissolved with 15.0 parts by weight of D-tartaric acid in 150 parts by volume
of hot alcohol. The solution is cooled and seeded with (+)-3-methoxy-Nmethyl-morphinan-tartrate.The (+)-form which is difficultly soluble in alcohol
separates, is filtered by suction and washed with a little alcohol.
[The (-)-form may be crystallized from the residue obtained by concentrating
the mother liquor, separating therefrom as much as possible of the (+)-form
and adding acetone].
The (+)-3-methoxy-N-methyl-morphinan-tartrate melts with 1 mol of water at
195°-196°C [α]D20 =+30.6° (c = 1.5 in water). The (+) base melting at
108°-109°C may be obtained from the tartrate by means of sodium
carbonate. The corresponding hydrobromide melts at 122°-124°C [α]D20
=+27.6° (c = 1.5 in water).
brand name
Benylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare).
Therapeutic Function
Antitussive
Properties of DEXTROMETHORPHAN HYDROBROMIDE
Melting point: | 125-127℃ |
alpha | D20 +27.6° (c = 1.5 in water) |
pka | pKa 8.83(50%
aq EtOH) (Uncertain) |
form | Solid |
Water Solubility | Soluble in water (40 mM), and alcohol (1:10). |
EPA Substance Registry System | Morphinan, 3-methoxy-17-methyl-, hydrobromide (1:1),(9.alpha.,13.alpha.,14.alpha.)- (125-69-9) |
Safety information for DEXTROMETHORPHAN HYDROBROMIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. |
Computed Descriptors for DEXTROMETHORPHAN HYDROBROMIDE
Abamectin manufacturer
Attar Global
Pharma Links
Bazayan & Co.
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