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HomeProduct name listAntazoline hydrochloride

Antazoline hydrochloride

Synonym(s):2-(N-Benzylanilinomethyl)-2-imidazoline hydrochloride

  • CAS NO.:2508-72-7
  • Empirical Formula: C17H20ClN3
  • Molecular Weight: 301.81
  • MDL number: MFCD00058145
  • EINECS: 219-719-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-16 15:32:52
Antazoline hydrochloride Structural

What is Antazoline hydrochloride?

Chemical properties

White or almost white crystalline powder

Originator

Antistine HCl,Ciba,US,1948

The Uses of Antazoline hydrochloride

Antazoline Hydrochloride acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.

The Uses of Antazoline hydrochloride

Antihistaminic;H1 antagonist

The Uses of Antazoline hydrochloride

Imidazoline binding site ligand and an antihistamine

What are the applications of Application

Antazoline hydrochloride is an anticholinergic and antihistamine agent

Manufacturing Process

15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline and 150 parts of alcohol are heated in an oil bath at 100° to 110°C. After distilling off the alcohol, the reaction mass is maintained at this temperature for a further 3 hours and then triturated with water and 10 parts of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether and the aqueous solution neutralized with dilute hydrochloric acid. By evaporating this solution and extracting the residue with alcohol there is obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.

Therapeutic Function

Antihistaminic

Biological Activity

Imidazoline binding site ligand; a potent inducer of insulin secretion in rat pancreas. Also an antihistamine.

Properties of Antazoline hydrochloride

Melting point: 238 °C
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO (Slightly, Heated), Methanol (Slightly)
form  neat
form  Solid
color  White to Off-White
Merck  14,680
CAS DataBase Reference 2508-72-7(CAS DataBase Reference)

Safety information for Antazoline hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Antazoline hydrochloride

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