Antazoline hydrochloride
Synonym(s):2-(N-Benzylanilinomethyl)-2-imidazoline hydrochloride
- CAS NO.:2508-72-7
- Empirical Formula: C17H20ClN3
- Molecular Weight: 301.81
- MDL number: MFCD00058145
- EINECS: 219-719-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-16 15:32:52
What is Antazoline hydrochloride?
Chemical properties
White or almost white crystalline powder
Originator
Antistine HCl,Ciba,US,1948
The Uses of Antazoline hydrochloride
Antazoline Hydrochloride acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.
The Uses of Antazoline hydrochloride
Antihistaminic;H1 antagonist
The Uses of Antazoline hydrochloride
Imidazoline binding site ligand and an antihistamine
What are the applications of Application
Antazoline hydrochloride is an anticholinergic and antihistamine agent
Manufacturing Process
15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline and 150 parts of alcohol are heated in an oil bath at 100° to 110°C. After distilling off the alcohol, the reaction mass is maintained at this temperature for a further 3 hours and then triturated with water and 10 parts of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether and the aqueous solution neutralized with dilute hydrochloric acid. By evaporating this solution and extracting the residue with alcohol there is obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.
Therapeutic Function
Antihistaminic
Biological Activity
Imidazoline binding site ligand; a potent inducer of insulin secretion in rat pancreas. Also an antihistamine.
Properties of Antazoline hydrochloride
Melting point: | 238 °C |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
form | neat |
form | Solid |
color | White to Off-White |
Merck | 14,680 |
CAS DataBase Reference | 2508-72-7(CAS DataBase Reference) |
Safety information for Antazoline hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Antazoline hydrochloride
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