AMINOGUANIDINE HYDROCHLORIDE

CAS NO.：1937-19-5
Empirical Formula: CH7ClN4
Molecular Weight: 110.54608
MDL number: MFCD00039074
EINECS: 217-707-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is AMINOGUANIDINE HYDROCHLORIDE?

Description

Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC₅₀ values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 μM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.

Chemical properties

white to off-white crystals

The Uses of AMINOGUANIDINE HYDROCHLORIDE

Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

The Uses of AMINOGUANIDINE HYDROCHLORIDE

antitussive

The Uses of AMINOGUANIDINE HYDROCHLORIDE

a-Glucosidase inhibitor; hydroxyethyl derivative of 1-deoxynojirimycin

What are the applications of Application

Aminoguanidine hydrochloride is an irreversible and selective inhibitor of NOS2

General Description

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Inhibits both constitutive and inducible nitric oxide synthetase.

Properties of AMINOGUANIDINE HYDROCHLORIDE

Melting point:	162-166 °C(lit.)
vapor pressure	0Pa at 25℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Completely soluble in water
form	Crystals
color	White to off-white
Water Solubility	506.7g/L at 20℃
Merck	13,440
BRN	3909606
CAS DataBase Reference	1937-19-5(CAS DataBase Reference)
EPA Substance Registry System	Hydrazinecarboximidamide, monohydrochloride (1937-19-5)

Safety information for AMINOGUANIDINE HYDROCHLORIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H317:Sensitisation, Skin H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.