Alverine citrate
Synonym(s):N-Ethyl-3,3′-diphenyldipropylamine;NSC 35459
- CAS NO.:5560-59-8
- Empirical Formula: C26H35NO7
- Molecular Weight: 473.57
- MDL number: MFCD00035086
- EINECS: 226-929-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 19:38:33
What is Alverine citrate?
Chemical properties
White or almost white, crystalline powder.
Originator
Alverine citrate,Kemikos
The Uses of Alverine citrate
An adrenergic-β3 receptor agonist. Antispasmodic.
The Uses of Alverine citrate
anticholinergic
The Uses of Alverine citrate
Used for studies of pharmacological activity including:
- Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
- Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
- Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
- Drug effects viewed from a signal transduction network perspective
- Enhanced cytotoxic effect of proteasome inhibitor MG132
- Mechanism of action on phasic smooth muscles
What are the applications of Application
Alverine Citrate is an β3-AR (adrenergic-β3 receptor) agonist and an inhibitor of SR-1A.
Definition
ChEBI: The citrate salt of alverine, resulting from the reaction of equimolar amounts of alvarine and citric acid. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used in the treatment of irritable bowel syndrome.
Manufacturing Process
2 Methods of producing of alverine:
1. 3-Phenylpropylchloride reacted with ethylamine in the presence potassium
hydroxide and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
2. 3-Phenylpropenal reacted with ethylamine in the presence hydrogen and Pt
as catalyst and BaSO4 and N-ethyl-3,3'-diphenyldipropylamine (alverine) was
obtained.
In practice it is usually used as citrate.
Therapeutic Function
Anticholinergic, Spasmolytic
Properties of Alverine citrate
Melting point: | 100-102° |
storage temp. | 2-8°C |
solubility | Slightly soluble in water and in methylene chloride, sparingly soluble in ethanol (96 per cent). |
form | neat |
form | Solid |
color | White to Off-White |
CAS DataBase Reference | 5560-59-8(CAS DataBase Reference) |
Safety information for Alverine citrate
Computed Descriptors for Alverine citrate
InChIKey | RYHCACJBKCOBTJ-UHFFFAOYSA-N |
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
You may like
-
Alverine citrate salt 98% (HPLC) CAS 5560-59-8View Details
5560-59-8 -
Alverine citrate salt CAS 5560-59-8View Details
5560-59-8 -
Dechloro DesloratadineView Details
-
Dehydro DesloratadineView Details
-
Edoxaban Impurity 57View Details
2089454-69-1 -
Empagliflozin Bromo ImpurityView Details
-
Glycopyrronium Bromide EP Impurity IView Details
1404617-94-2 -
Ipratropium EP Impurity BView Details
58073-59-9