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HomeProduct name listAlverine citrate

Alverine citrate

Synonym(s):N-Ethyl-3,3′-diphenyldipropylamine;NSC 35459

  • CAS NO.:5560-59-8
  • Empirical Formula: C26H35NO7
  • Molecular Weight: 473.57
  • MDL number: MFCD00035086
  • EINECS: 226-929-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Alverine citrate Structural

What is Alverine citrate?

Chemical properties

White or almost white, crystalline powder.

Originator

Alverine citrate,Kemikos

The Uses of Alverine citrate

An adrenergic-β3 receptor agonist. Antispasmodic.

The Uses of Alverine citrate

anticholinergic

The Uses of Alverine citrate

Used for studies of pharmacological activity including:

  • Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
  • Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
  • Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Drug effects viewed from a signal transduction network perspective
  • Enhanced cytotoxic effect of proteasome inhibitor MG132
  • Mechanism of action on phasic smooth muscles

What are the applications of Application

Alverine Citrate is an β3-AR (adrenergic-β3 receptor) agonist and an inhibitor of SR-1A.

Definition

ChEBI: The citrate salt of alverine, resulting from the reaction of equimolar amounts of alvarine and citric acid. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used in the treatment of irritable bowel syndrome.

Manufacturing Process

2 Methods of producing of alverine:
1. 3-Phenylpropylchloride reacted with ethylamine in the presence potassium hydroxide and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
2. 3-Phenylpropenal reacted with ethylamine in the presence hydrogen and Pt as catalyst and BaSO4 and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
In practice it is usually used as citrate.

Therapeutic Function

Anticholinergic, Spasmolytic

Properties of Alverine citrate

Melting point: 100-102°
storage temp.  2-8°C
solubility  Slightly soluble in water and in methylene chloride, sparingly soluble in ethanol (96 per cent).
form  neat
form  Solid
color  White to Off-White
CAS DataBase Reference 5560-59-8(CAS DataBase Reference)

Safety information for Alverine citrate

Computed Descriptors for Alverine citrate

InChIKey RYHCACJBKCOBTJ-UHFFFAOYSA-N

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