Aluminum trifluoromethanesulfonate
Synonym(s):Aluminum triflate;Aluminum tris(trifluoromethanesulfonate);Tris(trifluoromethanesulfonato)aluminum
- CAS NO.:74974-61-1
- Empirical Formula: CH4AlF3O3S
- Molecular Weight: 180.08
- MDL number: MFCD00143596
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is Aluminum trifluoromethanesulfonate?
Chemical properties
White powder
The Uses of Aluminum trifluoromethanesulfonate
Lewis acid used as a catalyst for Friedel–Crafts, ketalization, nucleophilic substitution, hydroalkoxylation, methoxycarbonyla- tion, rearrangement, and epoxide ring-opening reactions.
The Uses of Aluminum trifluoromethanesulfonate
Aluminum trifluoromethanesulfonate is used in pharmaceutical intermediates.
Preparation
Can be prepared from aluminum trichloride and tribromide by heating with triflic acid in anhydrous conditions. Preparations from triethylaluminum, aluminum carbide, and aluminum isopropoxide have also been described.
Reactions
Friedel-Crafts Reactions.
Aluminum trifluoromethanesulfonate has been used for the Friedel-Crafts alkylation reaction of toluene with isopropyl and tert-butyl chlorides (eq 1), and for theacylationofbenzeneandtoluenewithacetylandbenzoylchlo- rides in low to moderate yields. Intramolecular Friedel-Crafts acylation of an aromatic compound with Meldrum’s acid has also been reported using catalytic amounts of Al(OTf) 3 . Acylation of 2-methoxynaphthalene with acetic anhydride has been reported using Al(OTf) 3 and lithium perchlorate as an additive to afford the corresponding 6-acetylated adduct in 83% yield. Effective acylation of arenes with carboxylic acids has also been disclosed using polystyrene-supported Al(OTf)3.
Properties of Aluminum trifluoromethanesulfonate
Melting point: | 300 °C(lit.) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | soluble in ether, acetone, acetonitrile, and diglyme; poorly soluble in nitromethane; sparingly soluble in SO2 and SO2 ClF. |
form | Powder |
color | White |
Water Solubility | Insoluble in water. |
Sensitive | Hygroscopic |
Hydrolytic Sensitivity | 6: forms irreversible hydrate |
Stability: | hygroscopic |
CAS DataBase Reference | 74974-61-1(CAS DataBase Reference) |
Safety information for Aluminum trifluoromethanesulfonate
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Aluminum trifluoromethanesulfonate
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