alpha,alpha'-Dibromo-p-xylene

Chemical properties

α,α′-Dibromo-p-xylene is a white to light yellow crystal powde,it reacts with nucleophiles such as chloride leads to the formation of diphenyl ethers.

The Uses of alpha,alpha'-Dibromo-p-xylene

alpha,alpha'-Dibromo-p-xylene is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 7055, 1994 DOI: 10.1016/0040-4039(94)88224-X

Synthesis

The synthesis of alpha,alpha'-Dibromo-p-xylene begins with the reaction of pyridinedicarboxylic acid and bromine in the presence of an organic solvent. This reaction yields a mixture comprising diphenyl ethers and other halogenated aromatic compounds, which can subsequently be purified through crystallization or distillation methods.

Purification Methods

Distil it under a vacuum and recrystallise it from EtOH, *benzene or chloroform. [Wenner Org Chem 17 527 1952, Beilstein 5 H 385, 5 I 187, 5 II 301, 5 III 859, 5 IV 970.]