alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol)

Synonym(s):31-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontanoic acid 2,5-dioxo-1-pyrrolidinyl ester;31-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Maleimide PEG8 succinimidyl ester;Maleimide-PEG₈-NHS ester;Maleimide-PEG8-NHS ester

CAS NO.：756525-93-6
Empirical Formula: C30H47N3O15
Molecular Weight: 689.71
MDL number: MFCD11041144
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-27 14:23:05

alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol) Structural

What is alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol)?

Description

Mal-amido-PEG8-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

The Uses of alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol)

Heterobifunctional crosslinker with an ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 39.2 angstroms.

What are the applications of Application

Maleimide-PEG8-NHS ester is a heterobifunctional amine- and sulfhydryl-reactive crosslinker with a 39.2 angstrom ethylene oxide spacer arm

Properties of alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol)

Density	1.30±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO : ≥ 100 mg/mL (144.99 mM)
pka	15.01±0.46(Predicted)
color	Light yellowish

Safety information for alpha-MaleiMidopropionyl-oMega-succiniMidyl-8(ethylene glycol)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P233:Keep container tightly closed. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304:IF INHALED: P312:Call a POISON CENTER or doctor/physician if you feel unwell. P321:Specific treatment (see … on this label). P340:Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P403:Store in a well-ventilated place. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…