Maleimide-PEG2-NHS Ester
Synonym(s):3-[2-[2-[[3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]propanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Maleimide-PEG2-NHS
- CAS NO.：955094-26-5
- Empirical Formula: C18H23N3O9
- Molecular Weight: 425.39
- MDL number: MFCD11041137
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is Maleimide-PEG2-NHS Ester?
Description
Mal-amido-PEG2-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
The Uses of Maleimide-PEG2-NHS Ester
Heterobifunctional crosslinker with short ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 17.6 angstroms.
What are the applications of Application
Maleimide-PEG2-NHS is a heterobifunctional amine- and sulfhydryl-reactive crosslinker, 17.6 angstrom ethylene oxide spacer arm
Properties of Maleimide-PEG2-NHS Ester
| Melting point: | 90.0 to 94.0 °C |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| form | powder to crystal |
| pka | 15.00±0.46(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C18H23N3O9/c22-13(5-8-20-14(23)1-2-15(20)24)19-7-10-29-12-11-28-9-6-18(27)30-21-16(25)3-4-17(21)26/h1-2H,3-12H2,(H,19,22) |
Safety information for Maleimide-PEG2-NHS Ester
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Maleimide-PEG2-NHS Ester
| InChIKey | TZPDZOJURBVWHS-UHFFFAOYSA-N |
| SMILES | C(ON1C(=O)CCC1=O)(=O)CCOCCOCCNC(=O)CCN1C(=O)C=CC1=O |
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