Maleimide-PEG2-NHS Ester

Synonym(s):3-[2-[2-[[3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]propanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Maleimide-PEG₂-NHS

CAS NO.：955094-26-5
Empirical Formula: C18H23N3O9
Molecular Weight: 425.39
MDL number: MFCD11041137
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is Maleimide-PEG2-NHS Ester?

Description

Mal-amido-PEG2-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

The Uses of Maleimide-PEG2-NHS Ester

Heterobifunctional crosslinker with short ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 17.6 angstroms.

What are the applications of Application

Maleimide-PEG2-NHS is a heterobifunctional amine- and sulfhydryl-reactive crosslinker, 17.6 angstrom ethylene oxide spacer arm

Properties of Maleimide-PEG2-NHS Ester

Melting point:	90.0 to 94.0 °C
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	-20°C
form	powder to crystal
pka	15.00±0.46(Predicted)
color	White to Light yellow
InChI	InChI=1S/C18H23N3O9/c22-13(5-8-20-14(23)1-2-15(20)24)19-7-10-29-12-11-28-9-6-18(27)30-21-16(25)3-4-17(21)26/h1-2H,3-12H2,(H,19,22)

Safety information for Maleimide-PEG2-NHS Ester

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.