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HomeProduct name listMal-PEG2-acid

Mal-PEG2-acid

  • CAS NO.:1374666-32-6
  • Empirical Formula: C11H15NO6
  • Molecular Weight: 257.24
  • MDL number: MFCD23726620
  • Update Date: 2024-10-28 23:16:16
Mal-PEG2-acid Structural

What is Mal-PEG2-acid?

Description

Mal-PEG2-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Mal-PEG2-acid is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It can bind to Tubulysin (HY-128914) and its cytotoxic derivatives activity. It can also be used as a PROTAC linker for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Properties of Mal-PEG2-acid

Boiling point: 455.7±35.0 °C(Predicted)
Density  1.329±0.06 g/cm3(Predicted)
form  powder to crystal
pka 4.27±0.10(Predicted)
color  White to Light yellow
CAS DataBase Reference 1374666-32-6

Safety information for Mal-PEG2-acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Mal-PEG2-acid

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