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HomeProduct name listalpha-Lobeline hydrochloride

alpha-Lobeline hydrochloride

Synonym(s):α-Lobeline hydrochloride;(−)-Lobeline hydrochloride;L-Lobeline hydrochloride

  • CAS NO.:134-63-4
  • Empirical Formula: C22H28ClNO2
  • Molecular Weight: 373.92
  • MDL number: MFCD00082455
  • EINECS: 205-150-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
alpha-Lobeline hydrochloride Structural

What is alpha-Lobeline hydrochloride?

Description

(–)-Lobeline is an alkaloid that has been found in Lobelia and has diverse biological activities. It binds to nicotinic acetylcholine receptors (nAChRs) in rat brain homogenates (Ki = 4 nM) and has antinociceptive effects in the tail-flick assay in mice. (–)-Lobeline (0.3 and 0.9 mg/kg) reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats. It also decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test, indicating antidepressant-like activity, in mice when administered at doses of 1 and 4 mg/kg.

Chemical properties

White to Off-White Solid

The Uses of alpha-Lobeline hydrochloride

A neuronal nicotinic acetylcholine receptor agonist. A respiratory stimulant

The Uses of alpha-Lobeline hydrochloride

A neuronal nicotinic acetylcholine receptor agonist. A CNS stimulant.

What are the applications of Application

Lobeline hydrochloride is an AChR agonist

Biological Activity

High affinity nicotinic receptor ligand, with a K i value of 4.4 nM in rat brain.

in vitro

clastogenicity of lobeline and possible interactions between lobeline and ethyl alcohol were investigated in a mutagen-sensitivity assay on cultures of human lymphoblastoid cell lines. lobeline alone was not clastogenic, but there was a marked increase in genetic damage resulting from a coclastogenic interaction between lobeline and ethyl alcohol. [5]

in vivo

male c57bl/6j mice were individually housed and acclimatized to 10% alcohol. lobeline is a partial nicotinic agonist that attenuates alcohol consumption and preference in male c57bl/6j mice. [3] cf-1 male mice received an intraperitoneal injection of lobeline (5 or 10mg/kg). lobeline did not show genotoxic or mutagenic effects and did not increase the ethanol-induced genotoxic effects in blood. lobeline also protected blood cells against oxidative damage induced by hydrogen peroxide. [4]

Properties of alpha-Lobeline hydrochloride

Melting point: 183-185 °C (dec.)(lit.)
alpha  D20 -43° (c = 2)
refractive index  -57.5 ° (C=1, H2O)
storage temp.  Inert atmosphere,Room Temperature
solubility  H2O: 25 mg/mL
form  powder
color  white to off-white
optical activity [α]20/D 56.8°, c = 2 in H2O
Merck  14,5551
BRN  3920196
CAS DataBase Reference 134-63-4(CAS DataBase Reference)

Safety information for alpha-Lobeline hydrochloride

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06

Computed Descriptors for alpha-Lobeline hydrochloride

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