alpha-Bisabolol
- CAS NO.：515-69-5
- Empirical Formula: C15H26O
- Molecular Weight: 222.37
- MDL number: MFCD03846910
- EINECS: 208-205-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 13:32:20
What is alpha-Bisabolol?
Description
Bisabolol, a derivative of?Matricaria chamomilla?(German chamomile), helps administer active pharmaceutical ingredients transdermally by enhancing skin penetration. Bisabolol is also found in some lotions for reducing wrinkles and acne.
Chemical properties
colourless to faintly yellow viscous liquid
The Uses of alpha-Bisabolol
alpha-Bisabolol is a botanical used for its anti-inflammatory and soothing properties. It is derived from chamomile and/or yarrow.
The Uses of alpha-Bisabolol
It finds its application as a masking agent, skin conditioning agent and soothing agent in cosmetics industry. The most important effects of Bisabolol for the use in cosmetics are anti-inflammatory, wound-healing, anti-bacterial and anti-mycotic. Bisabolol is therefore perfectly suited for the use in all kinds of skin-care products It can be used as active substance in cosmetic preparations for the protection and care of sensitive skin, preparations for babies and children, sunscreen and after-sun products, aftershaves and preparations for the oral hygiene.
Definition
ChEBI: (+)-alpha-Bisabolol is a sesquiterpenoid.
Production Methods
rac-Bisabolol is produced by acid-catalyzed cyclization of farnesol or nerolidol. The individual enantiomers are obtained by extraction from the appropriate plants.
Preparation
Via Nerolidol plus glacial Acetic acid with Sulfuric acid to yield Bisabolol acetate, Saponification of that ester yields alpha-Bisabolol.
Safety Profile
Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.
Properties of alpha-Bisabolol
| Melting point: | 25°C |
| Boiling point: | 154-156°C |
| Density | 0.93 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | 135°C |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | Liquid |
| pka | 15.04±0.29(Predicted) |
| color | Clear Colourless |
| Odor | at 100.00 %. mild floral peppery balsamic clean |
| Water Solubility | Soluble in alcohol, natural, mineral and synthetic oils. Insoluble in water. |
| Merck | 14,1241 |
| BRN | 5733954 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 515-69-5(CAS DataBase Reference) |
| NIST Chemistry Reference | «ALPHA»-bisabolol(515-69-5) |
| EPA Substance Registry System | 3-Cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, (.alpha.R,1R)-rel- (515-69-5) |
Safety information for alpha-Bisabolol
Computed Descriptors for alpha-Bisabolol
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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