alpha-Azido-omega-hydroxy octa(ethylene glycol)
Synonym(s):Azido-PEG (n=7)
- CAS NO.:352439-36-2
- Empirical Formula: C16H33N3O8
- Molecular Weight: 395.45
- MDL number: MFCD08274607
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is alpha-Azido-omega-hydroxy octa(ethylene glycol)?
Description
Azide-PEG8-alcohol is a click chemistry reagent with an azide(N3) and a terminal hydroxyl group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl (OH) group enables further derivatization or replacement with other functional groups.
The Uses of alpha-Azido-omega-hydroxy octa(ethylene glycol)
O-(2-Azidoethyl)heptaethylene glycol is used to synthesize oligo and poly(ethylene glycol) derivatives that are used as structural units of dendrimers, hydrogels, surface modifiers, self-assembling systems and molecular crosslinkers. This precursor is compatible for acetylene-azide click reactions.
Some of the reported applications include:
- Synthesis of strain-stiffening hydrogels through self-assembly of oligomers fibres derived from Azido-PEG (n=7).
- Synthesis of biodegradable tetra-PEG hydrogels for drug delivery system.
- Synthesis of heterobifunctional oligo(ethylene glycol) linkers for bioconjugation and targeted drug delivery.
- Preparation of synthetic amphiphiles for programmed pH-dependent dispersions of carbon nanotubes (CNTs).
- Selective glycoprotein detection through allosteric click-imprinting by using a self-assembled monolayer developed from the above oligomer.
- Preparation of bioactivated quantum dot micelles containing fluorescent nanocrystals.
Properties of alpha-Azido-omega-hydroxy octa(ethylene glycol)
storage temp. | 2-8°C |
solubility | Soluble in Water, DMSO, DCM, DMF |
form | Liquid |
color | Colorless to light yellow |
BRN | 8940056 |
Safety information for alpha-Azido-omega-hydroxy octa(ethylene glycol)
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for alpha-Azido-omega-hydroxy octa(ethylene glycol)
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