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HomeProduct name listN3-PEG3-tBu

N3-PEG3-tBu

N3-PEG3-tBu Structural

What is N3-PEG3-tBu?

Description

Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

The Uses of N3-PEG3-tBu

Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides.

Biological Activity

N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Properties of N3-PEG3-tBu

form  Liquid
color  Colorless to light yellow

Safety information for N3-PEG3-tBu

Computed Descriptors for N3-PEG3-tBu

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