5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
- CAS NO.：437655-95-3
- Empirical Formula: C25H31NO8
- Molecular Weight: 473.52
- MDL number: MFCD26142981
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid?
Description
Fmoc-NH-PEG4-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Fmoc-NH-PEG4-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Properties of 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
| Melting point: | 51℃ |
| Boiling point: | 681.3±55.0 °C(Predicted) |
| Density | 1.235±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 3.39±0.10(Predicted) |
| color | Colorless to light yellow |
Safety information for 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
New Products
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