Alizapride

CAS NO.：59338-93-1
Empirical Formula: C16H21N5O2
Molecular Weight: 315.37
MDL number: MFCD00867757
EINECS: 261-710-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is Alizapride?

Originator

Plitican ,Delagrange ,France ,1981

Definition

ChEBI: 6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide is a member of benzotriazoles.

Manufacturing Process

38.6 g (0.2 mol) of 2-methoxy-4,5-azimidobenzoic acid were dissolved in anhydrous toluene and 56 g (0.4 mol) of 1-allyl-2-amino-methylpyrrolidine were added. The mixture was heated to 50°C and then 42 g (0.3 mol) of phosphoric anhydride were added. The mixture was warmed at reflux temperature for 3 hours and then cooled to 80°C. After adding water, the aqueous layer was alkalized. The crystals were filtered, washed with water and then dissolved in 450 ml of acetone. After crystallization, the product was 40.4 g (yield 65%) of N-(1'-allyl-2'-pyrrolidylmethyl)-2-methoxy-4,5- azimidobenzamide having a melting point of 139°C were obtained.

Therapeutic Function

Neuroleptic, Antiemetic

Properties of Alizapride

Melting point:	139°
Boiling point:	580.3±40.0 °C(Predicted)
Density	1.224±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
pka	7.09±0.40(Predicted)
CAS DataBase Reference	59338-93-1(CAS DataBase Reference)

Safety information for Alizapride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.