Mosapride
- CAS NO.:112885-41-3
- Empirical Formula: C21H25ClFN3O3
- Molecular Weight: 421.89
- MDL number: MFCD00867430
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is Mosapride?
Description
Mosapride citrate, a new gastroprokinetic benzamide was introduced in Japan as Gasmotin for the relief of gastrointestinal symptoms in patients with chronic gastritis, gastro-oesophageal reflux, dyspepsia and post-surgery use. Mosapride is synthesized by final amidation between the corresponding benzoic acid, itself obtained in 3 steps from methyl 4-acetamido salicylate, and the appropriate 2-aminomethyl-morpholine. Mosapride is a 5-HT4 partial agonist without notable activity for D2, 5-HT1 , 5-HT2, alpha-1 and alpha-2 receptors. In dogs, mosapride was as potent as cisapride to stimulate antral and duodenal motility. In most of species including man, mosapride undergoes extensive cleavage to a N-debenzylated metabolite which retains partial 5-HT4 activity but has potent 5-HT3 antagonist activity.
Chemical properties
White to Off-White Crystalline Solid
Originator
Dainippon (Japan)
The Uses of Mosapride
A selective 5-HT4 receptor agonist. Gastroprokinetic.
The Uses of Mosapride
gastroprokinetic agent
What are the applications of Application
Mosapride is a gastroprokinetic, selective SR-4 (5-HT4 receptor) agonist
Definition
ChEBI: Mosapride is a racemate comprising equimolar amounts of (R)- and (S)-mosapride. It is a gastroprokinetic agent which acts on 5-hydroxytryptamine type 4 (5-HT4) receptors in the gastrointestinal plexus, consequently increasing the release of acetylcholine and hence enhancing gastrointestinal motility and gastric emptying. It has a role as a gastrointestinal drug and a serotonergic agonist. It contains a (R)-mosapride and a (S)-mosapride.
brand name
Gasmotin
Hazard
A poison by ingestion.
Safety Profile
A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx, F-, and Cl-.
Properties of Mosapride
Melting point: | 151-153°C |
Boiling point: | 549.2±50.0 °C(Predicted) |
Density | 1.272±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 13.52±0.46(Predicted) |
color | White to Off-White |
CAS DataBase Reference | 112885-41-3(CAS DataBase Reference) |
Safety information for Mosapride
Computed Descriptors for Mosapride
New Products
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