alinastine
- CAS NO.:154541-72-7
- Empirical Formula: C28H39N3O
- Molecular Weight: 433.636
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is alinastine?
Originator
Alinastine ,Fabrica Espanola de Productos Quimicos y Farmaceuticos
Manufacturing Process
1.5 g of a sodium hydride suspension in oil are added to another suspension of 10.83 g of 2-[1-(2-(4-(1,1-dimethylethyl)phenyl)ethyl)piperidin-4-yl]-1Hbenzimidazole in 150 ml of dimethylformamide and the mixture is stirred for 1 h at room temperature, then a solution of 2-(2-ethoxyethyl)tosylate in dimethylformamide are slowly added. The mixture is heated at 60°C for 16 h, poured onto water and extracted with ether. The extracts are washed with water, dried over anhydrous sodium sulfate and concentrated. The obtained oil is purified by column chromatography yielding 6.0 g of 1-(2-ethoxyethyl)-2- [1-(2-(4-(1,1-dimethylethyl)phenyl)ethyl)piperidine-4-yl]-1H-benzimidazole, melting point 138°-140°C.
Therapeutic Function
Antihistaminic, Antiallergic
Properties of alinastine
Boiling point: | 574.2±50.0 °C(Predicted) |
Density | 1.07±0.1 g/cm3(Predicted) |
pka | 8.78±0.10(Predicted) |
Safety information for alinastine
Computed Descriptors for alinastine
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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