AG 1478 HYDROCHLORIDE
- CAS NO.：153436-53-4
- Empirical Formula: C16H14ClN3O2
- Molecular Weight: 315.75
- MDL number: MFCD06804597
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:01:57
What is AG 1478 HYDROCHLORIDE?
The Uses of AG 1478 HYDROCHLORIDE
AG 1478 Hydrochloride is an epidermal growth factor receptor tyrosine kinase inhibior (EGFR inhibtor).
The Uses of AG 1478 HYDROCHLORIDE
A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.
Definition
ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.
Biological Activity
Potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC 50 = 1 μ M).
Properties of AG 1478 HYDROCHLORIDE
| Melting point: | 247 °C(dec.) |
| Boiling point: | 458.5±45.0 °C(Predicted) |
| Density | 1.337 |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | insoluble in H2O; ≥15.8 mg/mL in DMSO; ≥2.38 mg/mL in EtOH with gentle warming |
| form | White to light yellow solid. |
| pka | 5.54±0.30(Predicted) |
| color | Light orange to Yellow to Green |
| λmax | 332nm(lit.) |
Safety information for AG 1478 HYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for AG 1478 HYDROCHLORIDE
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