AG 1478 HYDROCHLORIDE

CAS NO.：153436-53-4
Empirical Formula: C16H14ClN3O2
Molecular Weight: 315.75
MDL number: MFCD06804597
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 21:39:59

What is AG 1478 HYDROCHLORIDE?

The Uses of AG 1478 HYDROCHLORIDE

AG 1478 Hydrochloride is an epidermal growth factor receptor tyrosine kinase inhibior (EGFR inhibtor).

The Uses of AG 1478 HYDROCHLORIDE

A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.

Definition

ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.

Biological Activity

Potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC 50 = 1 μ M).

Properties of AG 1478 HYDROCHLORIDE

Melting point:	247 °C(dec.)
Boiling point:	458.5±45.0 °C(Predicted)
Density	1.337
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	insoluble in H2O; ≥15.8 mg/mL in DMSO; ≥2.38 mg/mL in EtOH with gentle warming
form	White to light yellow solid.
pka	5.54±0.30(Predicted)
color	Light orange to Yellow to Green
λmax	332nm(lit.)

Safety information for AG 1478 HYDROCHLORIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.