Adavivint
- CAS NO.:1467093-03-3
- Empirical Formula: C29H24FN7O
- Molecular Weight: 505.55
- MDL number: MFCD30489411
- Update Date: 2024-07-02 08:55:03
What is Adavivint?
The Uses of Adavivint
Adavivint is an intra-articular potential disease-modifying osteoarthritis drug.
Biological Activity
Adavivint (SM04690) is a potent canonical Wnt signaling pathway inhibitor with EC50 of 19.5 nM for TCF/LEF reporter gene. It was more potent than other known Wnt inhibitors in multiple cellular experiments.
in vitro
Treatment of bone marrow-derived human mesenchymal stem cells (CD29+, CD44+ CD166+ CD105+ CD45-) with SM04690 induced a concentration-dependent decrease in Wnt pathway gene expression (ASCL1, LEF1, TCF7L2, TCF7 , C-262 MYC and AXIN2). Selective activation of Wnt signaling pathway with Wnt3a or GSK3β inhibitor CHIR-99021, in IEC6 (intestinal stem cells sensitive to Wnt activation), M04690 can inhibit the expression of AXIN2 and LGR5; in hMSCs, inhibit the expression of AXIN2, TCF7 and LEF1 Express. It has minimal effects on non-canonical Wnt signaling and BMP signaling. In vitro, SM04690 protects chondrocytes from metabolic breakdown.
in vivo
Intra-articular injection of Adavivint promotes cartilage growth and improves joint health in a rat model of knee osteoarthritis. In vivo, it reduces cartilage breakdown.
Properties of Adavivint
Density | 1.365±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO:27.5(Max Conc. mg/mL);54.4(Max Conc. mM) |
pka | 7.75±0.40(Predicted) |
form | Solid |
color | Light yellow to gray |
Safety information for Adavivint
Computed Descriptors for Adavivint
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