3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Synonym(s):(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide;3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
- CAS NO.:1164470-53-4
- Empirical Formula: C18H15Cl4N3OS
- Molecular Weight: 463.21
- MDL number: MFCD00361095
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide?
The Uses of 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.
What are the applications of Application
eIF-2α Inhibitor II, Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal
Biological Activity
eukaryotic initiation factor 2 α-subunit (eif2α) plays a critical role in the regulation of protein synthesis. moreover, it also plays an important role in synaptic plasticity and long-term memory consolidation. sal003 is a selective inhibitor of eif2α dephosphorylation.
Biochem/physiol Actions
Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.
in vitro
sal003 specifically prevents dephosphorylation of eif2α by blocking eif2α phosphatases. in sal003-treated cells polysomes dissociated and consistent with this β-actin mrna shifted to lighter fractions, reflecting the inhibition of general translation [1].
in vivo
intra-basolateral amygdala (bla) infusions of sal003 immediately after memory retrieval disrupted the reconsolidation of morphine- or cocaine-induced cpp, leading to a long-lasting suppression of drug-paired stimulus-induced craving. moreover, inhibition of eif2α dephosphorylation in the bla immediately after light/tone stimulus retrieval decreased subsequent cue-induced heroin-seeking behavior in the self-administration procedure. these results demonstrate that eif2α dephosphorylation in the bla mediates the memory reconsolidation of drug-paired stimuli [1].
storage
Store at -20°C
References
[1] jian m, luo yx, xue yx, han y, shi hs, liu jf, yan w, wu p, meng sq, deng jh, shen hw, shi j, lu l. eif2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. j neurosci. 2014;34(30):10010-21.
Properties of 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
storage temp. | 2-8°C |
solubility | DMSO: ≥10mg/mL |
form | powder |
color | white to off-white |
Safety information for 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Signal word | Warning |
Pictogram(s) |
Environment GHS09 |
GHS Hazard Statements |
H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
New Products
Tubulysin I (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin C Tubulysin H Tubulysin D Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2H-Pyran, 4-ethynyltetrahydro- CYCLOBUTYLAMINE HYDROCHLORIDE tetrahydro-4-methyl-2H-pyran 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 1-(1,1-Difluoroethyl)-2-fluorobenzene 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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