ABBV-744

CAS NO.：2138861-99-9
Empirical Formula: C28H30FN3O4
Molecular Weight: 491.55
MDL number: MFCD31657409
Update Date: 2024-07-02 08:55:11

What is ABBV-744?

The Uses of ABBV-744

ABBV 744 is a bromodomain and extra-??terminal (BET) inhibitor used as a combination therapy for cancer treatment.

Biological Activity

ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It can be further studied for the treatment of acute myeloid leukemia and cancer.

in vitro

ABBV-744 is a potent BDII inhibitor that inhibits BRD2/3/4. The binding preference for BDII is more than 250 times that for BDI, with favorable drug-like properties. It is also an inhibitor of the androgen receptor transduction pathway.

in vivo

The maximum tolerated dose of ABBV-744 induces tumor growth inhibition in AML and prostate cancer xenograft models.

Properties of ABBV-744

Boiling point:	663.7±55.0 °C(Predicted)
Density	1.262±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:33.57(Max Conc. mg/mL);68.29(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.51(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);61.03(Max Conc. mM)
form	A crystalline solid
pka	13.77±0.40(Predicted)
color	White to light yellow