ABBV-744
- CAS NO.：2138861-99-9
- Empirical Formula: C28H30FN3O4
- Molecular Weight: 491.55
- MDL number: MFCD31657409
- Update Date: 2024-07-02 08:55:11
What is ABBV-744?
The Uses of ABBV-744
ABBV 744 is a bromodomain and extra-??terminal (BET) inhibitor used as a combination therapy for cancer treatment.
Biological Activity
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It can be further studied for the treatment of acute myeloid leukemia and cancer.
in vitro
ABBV-744 is a potent BDII inhibitor that inhibits BRD2/3/4. The binding preference for BDII is more than 250 times that for BDI, with favorable drug-like properties. It is also an inhibitor of the androgen receptor transduction pathway.
in vivo
The maximum tolerated dose of ABBV-744 induces tumor growth inhibition in AML and prostate cancer xenograft models.
Properties of ABBV-744
| Boiling point: | 663.7±55.0 °C(Predicted) |
| Density | 1.262±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:33.57(Max Conc. mg/mL);68.29(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.51(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);61.03(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.77±0.40(Predicted) |
| color | White to light yellow |
Safety information for ABBV-744
Computed Descriptors for ABBV-744
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