Actarit

CAS NO.：18699-02-0
Empirical Formula: C10H11NO3
Molecular Weight: 193.2
MDL number: MFCD00196165
EINECS: 242-511-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Actarit?

Description

Actarit is an orally administered disease-modifying antirheumatic drug launched in Japan. Although its structure resembles that of non-steroidal anti-inflammatory drugs, it has no effect on experimental acute inflammation and has no analgesic or antipyretic effects. Its preventative and therapeutic effects on adjuvant arthritis are mediated via modulation of production and serum level of interleukin-2 which enhances production of suppressor T-cells to the immune system, thereby, preventing development of articular lesions.

Chemical properties

Crystalline Solid

Originator

Nippon Shlnyaku;Mltaublshl Kasel (Japan)

The Uses of Actarit

Antiarthritic

The Uses of Actarit

Chronic rheumatoid arthritis

What are the applications of Application

Actarit is Actarit is an anti-arthritic.

Definition

ChEBI: Actarit is an anilide and a member of acetamides.

brand name

Orcl; Mover

Purification Methods

Crystallise the acid from MeOH/Me2CO, aqueous EtOH or H2O. The amide has m 231o (from 50% aqueous EtOH). [Gabriel Chem Ber 15 841 1882, Cerecedo et al. J Biol Chem 42 238 1924, Tramontano et al. J Am Chem Soc 110 2282 1988, Beilstein 14 II 281.]

Properties of Actarit

Melting point:	173-175°C
Boiling point:	449.1±28.0 °C(Predicted)
Density	1.288±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO, Ethanol, Methanol
form	Solid
pka	4.34±0.10(Predicted)
color	White to Off-White
Merck	14,133
CAS DataBase Reference	18699-02-0(CAS DataBase Reference)

Safety information for Actarit

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.