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HomeProduct name listActarit

Actarit

  • CAS NO.:18699-02-0
  • Empirical Formula: C10H11NO3
  • Molecular Weight: 193.2
  • MDL number: MFCD00196165
  • EINECS: 242-511-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Actarit Structural

What is Actarit?

Description

Actarit is an orally administered disease-modifying antirheumatic drug launched in Japan. Although its structure resembles that of non-steroidal anti-inflammatory drugs, it has no effect on experimental acute inflammation and has no analgesic or antipyretic effects. Its preventative and therapeutic effects on adjuvant arthritis are mediated via modulation of production and serum level of interleukin-2 which enhances production of suppressor T-cells to the immune system, thereby, preventing development of articular lesions.

Chemical properties

Crystalline Solid

Originator

Nippon Shlnyaku;Mltaublshl Kasel (Japan)

The Uses of Actarit

Antiarthritic

The Uses of Actarit

Chronic rheumatoid arthritis

What are the applications of Application

Actarit is Actarit is an anti-arthritic.

Definition

ChEBI: Actarit is an anilide and a member of acetamides.

brand name

Orcl; Mover

Purification Methods

Crystallise the acid from MeOH/Me2CO, aqueous EtOH or H2O. The amide has m 231o (from 50% aqueous EtOH). [Gabriel Chem Ber 15 841 1882, Cerecedo et al. J Biol Chem 42 238 1924, Tramontano et al. J Am Chem Soc 110 2282 1988, Beilstein 14 II 281.]

Properties of Actarit

Melting point: 173-175°C
Boiling point: 449.1±28.0 °C(Predicted)
Density  1.288±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  DMSO, Ethanol, Methanol
form  Solid
pka 4.34±0.10(Predicted)
color  White to Off-White
Merck  14,133
CAS DataBase Reference 18699-02-0(CAS DataBase Reference)

Safety information for Actarit

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Actarit

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