ACPT-I
- CAS NO.:194918-76-8
- Empirical Formula: C8H11NO6
- Molecular Weight: 217.18
- MDL number: MFCD06795869
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is ACPT-I?
Description
ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 μM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 μM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 and flumazenil , indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor.
The Uses of ACPT-I
ACPT-I is a competitive antagonist for metabotropic receptors (mGluRs).
Biological Activity
Agonist for group III mGlu receptors (EC 50 values are 7.2 and 8.2 μ M for mGlu 4a and mGlu 8 respectively). Anticonvulsant in mice.
storage
Desiccate at -20°C
Properties of ACPT-I
Boiling point: | 440.4±45.0 °C(Predicted) |
Density | 1.651±0.06 g/cm3(Predicted) |
storage temp. | Desiccate at -20°C |
solubility | Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH |
form | Powder |
pka | 1.85±0.60(Predicted) |
Safety information for ACPT-I
Computed Descriptors for ACPT-I
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