Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listAcetyl tributyl citrate

Acetyl tributyl citrate

Synonym(s):2-(Acetyloxy)-1,2,3-Propanetricarboxylic acid tributyl ester;Acetyl tributyl citrate;Tributyl 2-acetylcitrate;Tributylacetyl citrate

  • CAS NO.:77-90-7
  • Empirical Formula: C20H34O8
  • Molecular Weight: 402.48
  • MDL number: MFCD00043554
  • EINECS: 201-067-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 18:52:02
Acetyl tributyl citrate Structural

What is Acetyl tributyl citrate?

Chemical properties

clear colorless liquid

Chemical properties

Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

Chemical properties

Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

Chemical properties

Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.

The Uses of Acetyl tributyl citrate

Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.

The Uses of Acetyl tributyl citrate

plasticizer flavoring agent

The Uses of Acetyl tributyl citrate

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Definition

Aqueous-based pharmaceutical coat- ings.

Production Methods

Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

Preparation

From citric acid via the tributyl ester followed by acetylation.

Taste threshold values

An emulsion of the title material in water at 1000 ppm has only a very faint, mildly fruity-winey, berry-like odor and a mild, nondescript taste.

General Description

Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical Applications

Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes. ADD750

Safety

and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): >4 g/kg
LD50 (rat, oral): >31.5 g/kg

Carcinogenicity

The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.

Solubility in organics

Miscible with alcohol and oils.

storage

Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.

Incompatibilities

Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

Properties of Acetyl tributyl citrate

Melting point: -59 °C
Boiling point: 327 °C
Density  1.05 g/mL at 25 °C (lit.)
vapor pressure  0.26 psi ( 20 °C)
refractive index  n20/D 1.443(lit.)
FEMA  3080 | TRIBUTYL ACETYLCITRATE
Flash point: >230 °F
storage temp.  Store below +30°C.
solubility  Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
form  neat
form  Liquid
color  Clear Colourless
Odor at 100.00 %. very faint herbal wine sweet
Water Solubility  <0.1 g/100 mL
FreezingPoint  -80℃
JECFA Number 630
BRN  2303316
CAS DataBase Reference 77-90-7(CAS DataBase Reference)
NIST Chemistry Reference 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
EPA Substance Registry System Acetyl tributyl citrate (77-90-7)

Safety information for Acetyl tributyl citrate

Computed Descriptors for Acetyl tributyl citrate

InChIKey QZCLKYGREBVARF-UHFFFAOYSA-N

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.