Tributyl citrate

Chemical properties

Colorless or pale-yellow, stable, odorless, nonvolatile liquid. Practically insoluble in water. Combustible.

Chemical properties

Tributyl citrate is a clear, odorless, practically colorless, oily liquid.

The Uses of Tributyl citrate

Tributyl Citrate, is a non-phthalate plasticizer, that can be used for the preparation of resins. It can also used for the synthesis of Acetyl Tributyl Cirate, a valuable biodegradable plasticizer of low toxicity, found in nail polish and other cosmetics.

The Uses of Tributyl citrate

Plasticizer and solvent for nitrocellulose lacquers; in polishes, inks and similar Preparations; also as anti-foam agent.

The Uses of Tributyl citrate

Tributyl citrate can be used:

• To incorporate in zein film to enhance its mechanical properties for industrial processing.
• As a plasticizer to improve the ductile properties of poly(lactide) polymers.

What are the applications of Application

Tributyl citrate is added to zein film to enhance its mechanical properties for industrial processing.

Production Methods

Tributyl citrate is prepared by the esterification of citric acid with butanol.

Definition

ChEBI: Tributyl citrate is a carbonyl compound.

General Description

Tributyl citrate is an ester of citric acid. It is used to plasticize polymers for coating solid drug dosage forms, tablets and capsules.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.

Pharmaceutical Applications

Tributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release, and enteric formulations.

Safety

Tributyl citrate is used in oral pharmaceutical formulations. It is generally regarded as an essentially nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): 2.9 g/kg
LD50 (rat, oral): >30 mL/kg

storage

Tributyl citrate should be stored in well-closed containers in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, tributyl citrate is a stable material.

Incompatibilities

Tributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Approved in the USA for indirect food contact in food films. Included in the Canadian List of Acceptable Non-medicinal Ingredients.