Triethyl acetyl citrate

Synonym(s):Acetyl triethyl citrate;Triethyl 2-acetylcitrate

CAS NO.：77-89-4
Empirical Formula: C14H22O8
Molecular Weight: 318.32
MDL number: MFCD00049378
EINECS: 201-066-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-30 18:52:02

What is Triethyl acetyl citrate ?

Chemical properties

Acetyltriethyl citrate occurs as a clear, odorless, practically colorless oily liquid.

The Uses of Triethyl acetyl citrate

ATEC is produced by the reaction of citric acid triethyl ester with acetic acid anhydride. It is used as a solvent plasticizer for cellulose nitrate and cellulose acetate.

The Uses of Triethyl acetyl citrate

Triethyl O-Acetylcitrate is used in the preparation of poly(lactic) acid biodegradable and flexible films, acting as a plasticizer. Also used in the synthesis of control-release capsules containing polymeric coatings.

Definition

Aqueous-based pharmaceutical coat- ings.

Production Methods

Acetyltriethyl citrate is prepared by the esterification of citric acid with ethanol followed by acylation with acetic anhydride.

General Description

Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Triethyl 2-acetylcitrate is widely used in hydrophilic adhesives for medications and in biodegradable composition for papermaking and nonwoven production.

Pharmaceutical Applications

Acetyltriethyl citrate is used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads and granules for taste masking, immediate release, sustained-release and enteric formulations. It is also used in diffusion-controlled release drug delivery systems.

Safety

Acetyltriethyl citrate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD₅₀ (cat, oral): 8.5 g/kg
LD₅₀ (mouse, IP): 1.15 g/kg
LD₅₀ (rat, oral): 7 g/kg

storage

Acetyltriethyl citrate should be stored in dry, closed containers at temperatures not exceeding 388℃. When stored in accordance with these conditions, acetyltriethyl citrate is a stable product.

Incompatibilities

Acetyltriethyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Approved in the USA for direct food contact in food films.

Properties of Triethyl acetyl citrate

Melting point:	-42°C
Boiling point:	228-229 °C/100 mmHg (lit.)
Density	1.136 g/mL at 25 °C (lit.)
refractive index	n20/D 1.439(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble 1 in 140 of water; miscible with acetone, ethanol, and propan-2-ol.
form	neat
color	Colourless Thick
Odor	odorless
BRN	1804947
CAS DataBase Reference	77-89-4(CAS DataBase Reference)
NIST Chemistry Reference	1,2,3-Propanetricarboxylic acid, 2-acetoxy-, triethyl ester(77-89-4)
EPA Substance Registry System	1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester (77-89-4)

Safety information for Triethyl acetyl citrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.