Acethydrazide

Synonym(s):Acetic acid hydrazide;Acetylhydrazine

CAS NO.：1068-57-1
Empirical Formula: C2H6N2O
Molecular Weight: 74.08
MDL number: MFCD00007610
EINECS: 213-948-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 10:33:32

What is Acethydrazide?

Chemical properties

White moist crystals and chunks

The Uses of Acethydrazide

Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.

The Uses of Acethydrazide

Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.

The Uses of Acethydrazide

Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine.

Definition

ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,.

Purification Methods

Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]

Properties of Acethydrazide

Melting point:	58-68 °C (lit.)
Boiling point:	129 °C/18 mmHg (lit.)
Density	1.0968 (rough estimate)
refractive index	1.4264 (estimate)
Flash point:	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	13.46±0.18(Predicted)
form	Moist Crystals and Chunks
color	White
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	506165
CAS DataBase Reference	1068-57-1(CAS DataBase Reference)
NIST Chemistry Reference	Acetic acid, hydrazide(1068-57-1)
EPA Substance Registry System	Acetic acid hydrazide (1068-57-1)

Safety information for Acethydrazide

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H341:Germ cell mutagenicity H351:Carcinogenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.