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HomeProduct name listA 61603 HYDROBROMIDE

A 61603 HYDROBROMIDE

A 61603 HYDROBROMIDE Structural

What is A 61603 HYDROBROMIDE?

The Uses of A 61603 HYDROBROMIDE

A 61603 is a selective α1A-adrenergic receptor agonist.

What are the applications of Application

A 61603 HYDROBROMIDE is a potent α-adrenoceptor agonist

Biological Activity

Potent α -adrenoceptor agonist that is at least 35-fold more potent at α 1A than at α 1B or α 1D sites. Induces dose response increases in spontaneous Ca 2+ transients in rat ventricular myocytes in vitro (EC 50 = 6.9 nmol/L). Also available as part of the α 1 -Adrenoceptor Tocriset™ .

storage

Desiccate at +4°C

References

[1]. knepper sm, buckner sa, brune me, et al. a-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1a receptor subtype. j pharmacol exp ther, 1995, 274(1): 97-103.
[2]. meyer md, altenbach rj, hancock aa, et al. synthesis and in vitro characterization of n-[5-(4,5-dihydro-1h-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1a receptor agonist. j med chem, 1996, 39(20): 4116-4119.
[3]. luo dl, gao j, fan ll, et al. receptor subtype involved in alpha 1-adrenergic receptor-mediated ca2+ signaling in cardiomyocytes. acta pharmacol sin, 2007, 28(7): 968-974.
[4]. martínez-salas sg1, campos-peralta jm, pares-hipolito j, et al. alpha1a-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. auton autacoid pharmacol, 2007, 27(3): 137-142.

Properties of A 61603 HYDROBROMIDE

storage temp.  Desiccate at +4°C
solubility  Soluble in H2O
form  crystalline solid
color  White to off-white
Water Solubility  Soluble to 50 mM in water

Safety information for A 61603 HYDROBROMIDE

Computed Descriptors for A 61603 HYDROBROMIDE

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