Methanesulfonamide

Chemical properties

White to yellow crystals, powder or flakes

The Uses of Methanesulfonamide

• Methanesulfonamide is used in the synthesis of important organic reagents such as N-(2-methylthio-1-p-toluenesufonyl)methanesulfonamide and tert-butyl ((2-(trimethylsilyl)ethyl)sulfonyl)carbamate.
• It can be used as a source of nitrogen in the conversion of carboxylic acids to corresponding nitriles.
• It is widely used as a reagent in the synthesis of medicinally important compounds such as derivatives of indole-N-acetamide, methanesulfonamide pyrimidine-substituted 3,5-dihydroxy-6-heptenoates and repertaxin.

The Uses of Methanesulfonamide

Methanesulfonamide will react with thionyl chloride, cyanates, carbon disulfide and ketones and aldehydes to prepare pharmaceuticals, brightening agent and other target molecules. It is also used in biological studies to predict binding affinity and binding mode of protein ligand complexes.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 4096, 1968 DOI: 10.1021/ja01017a032
The Journal of Organic Chemistry, 60, p. 7682, 1995 DOI: 10.1021/jo00128a048
Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6