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HomeProduct name listNORFLUOXETINE HYDROCHLORIDE

NORFLUOXETINE HYDROCHLORIDE

NORFLUOXETINE HYDROCHLORIDE Structural

What is NORFLUOXETINE HYDROCHLORIDE?

Description

Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.

Chemical properties

NORFLUOXETINE HYDROCHLORIDE is Light Beige to Light Brown Solid

The Uses of NORFLUOXETINE HYDROCHLORIDE

Norfluoxetine Hydrochloride is a metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant.

The Uses of NORFLUOXETINE HYDROCHLORIDE

Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.

What are the applications of Application

Norfluoxetine Hydrochloride is A metabolite of Fluoxetine, a selective serotonin reuptake inhibitor

Biochem/physiol Actions

Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.

References

1) Veerman?et al.?(2013),?Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome;?Circ. Arrythm. Electrophysiol.?6?1002 2) Lutz?et al.?(2013),?Stereoselective inhibition of CYP2C1 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems;?Drug Metab. Dispos.?41?2056 3) Wong?et al.?(1993),?Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain;?Neuropsychopharmacology?8?337 4) Zuo?et al.?(2012),?Fluoxetine is a potent inhibitor of coxsackievirus replication.; Antimicrob. Agents Chemother.?56?4838 5) McClenaghan?et al.?(2016),?Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states; J. Gen. Physiol.?147?497

Properties of NORFLUOXETINE HYDROCHLORIDE

storage temp.  -20°C
solubility  H2O: >4 mg/mL
form  solid
color  yellow
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety information for NORFLUOXETINE HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for NORFLUOXETINE HYDROCHLORIDE

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