HYDROXYFASUDIL MONOHYDROCHLORIDE
Synonym(s):1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate;Hydroxyfasudil - CAS 155558-32-0 - Calbiochem;ROCK Inhibitor XIV, 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100
- CAS NO.：155558-32-0
- Empirical Formula: C14H18ClN3O3S
- Molecular Weight: 343.82902
- MDL number: MFCD06411567
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is HYDROXYFASUDIL MONOHYDROCHLORIDE?
Chemical properties
Off-White Solid
The Uses of HYDROXYFASUDIL MONOHYDROCHLORIDE
A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated ( ROCK) contraction both in vitro and in vivo. A
The Uses of HYDROXYFASUDIL MONOHYDROCHLORIDE
A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.
What are the applications of Application
Hydroxyfasudil Hydrochloride is a cell permeable metabolite of HA 1077
General Description
A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 μM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C
Properties of HYDROXYFASUDIL MONOHYDROCHLORIDE
| Melting point: | >250 (dec.) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: >5mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble in water (20mM) |
Safety information for HYDROXYFASUDIL MONOHYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for HYDROXYFASUDIL MONOHYDROCHLORIDE
| InChIKey | XWWFOUVDVJGNNG-UHFFFAOYSA-N |
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol](https://img.chemicalbook.in/CAS/GIF/649735-46-6.gif)
You may like
-
Hydroxyfasudil hydrochloride hydrate CAS 155558-32-0View Details
155558-32-0 -
Hydroxyfasudil CAS 155558-32-0View Details
155558-32-0 -
1975-50-4 98%View Details
1975-50-4 -
2-HYDROXY BENZYL ALCOHOL 98%View Details
90-01-7 -
2-Chloro-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 221615-75-4 98%View Details
221615-75-4 -
61397-56-6 CIS BROMO BENZOATE 98%View Details
61397-56-6 -
14714-50-2 (2-Hydroxyphenyl)acetonitrile 98+View Details
14714-50-2 -
118753-70-1 98+View Details
118753-70-1