HYDROXYFASUDIL MONOHYDROCHLORIDE
Synonym(s):1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate;Hydroxyfasudil - CAS 155558-32-0 - Calbiochem;ROCK Inhibitor XIV, 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100
- CAS NO.：155558-32-0
- Empirical Formula: C14H18ClN3O3S
- Molecular Weight: 343.82902
- MDL number: MFCD06411567
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is HYDROXYFASUDIL MONOHYDROCHLORIDE?
Chemical properties
Off-White Solid
The Uses of HYDROXYFASUDIL MONOHYDROCHLORIDE
A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated ( ROCK) contraction both in vitro and in vivo. A
The Uses of HYDROXYFASUDIL MONOHYDROCHLORIDE
A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.
What are the applications of Application
Hydroxyfasudil Hydrochloride is a cell permeable metabolite of HA 1077
General Description
A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 μM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C
Properties of HYDROXYFASUDIL MONOHYDROCHLORIDE
| Melting point: | >250 (dec.) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: >5mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble in water (20mM) |
Safety information for HYDROXYFASUDIL MONOHYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for HYDROXYFASUDIL MONOHYDROCHLORIDE
| InChIKey | XWWFOUVDVJGNNG-UHFFFAOYSA-N |
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