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HomeProduct name list7-Nitroindole-2-carboxylic acid

7-Nitroindole-2-carboxylic acid

Synonym(s):7-Nitro-1H-indole-2-carboxylic acid;7-Nitroindole-2carboxylic acid;7-Nitroindole-2-carboxylic acid, CRT0044876;DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem;NSC 69877

  • CAS NO.:6960-45-8
  • Empirical Formula: C9H6N2O4
  • Molecular Weight: 206.15
  • MDL number: MFCD00044720
  • EINECS: 230-154-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 21:40:10
7-Nitroindole-2-carboxylic acid Structural

What is 7-Nitroindole-2-carboxylic acid?

Chemical properties

brown powder

The Uses of 7-Nitroindole-2-carboxylic acid

7-Nitro-1H-indole-2-carboxylic Acid is a potent and selective APE1 inhibitor, which at low micromolar concentrations inhibits the AP endonuclease, 3''-phosphodiesterase and 3''-phosphatase activities of APE1 .

What are the applications of Application

DNA Base Excision Repair Pathway Inhibitor is a potent, nontoxic, and cell-permeable APE1 inhibitor

Biological Activity

crt0044876 is a potent and selective inhibitor of ape1 with ic50 value of 3.06 μm [1].apurinic/apyrimidinic endonuclease-1 (ape1) is a member of the highly conserved exonucleaseiii family of ap endonucleases and plays an important role in dna repair. ape1 exhibits 3’-phosphodiesterase activity and weak 3’-phosphatase activity, 3’-5’-exonuclease activity and rnaseh activity [1].crt0044876 is a potent and selective ape1 inhibitor. in hela whole cell extract, crt0044876 inhibited apurinic/apyrimidinic (ap) site cleavage catalyzed by ape1. crt0044876 inhibited both the ap endonuclease and exonuclease activities of exonuclease iii, the bacterial homologue of ape1. crt0044876 inhibited the 3’-phosphoglycolate diesterase activity of ape1 with ic50 value of 5 μm and also inhibited 3’-phosphatase activity through binding to dna repair active site of ape1. in ht1080 fibrosarcoma cells, crt0044876 significantly increased ap site accumulation and was non-toxic at concentrations up to 400 μm. also, crt0044876 potentiated the cytotoxicity induced by alkylating agent mms, temozolomide, hydrogen peroxide and hmdurd through specific inhibition of the base excision repair (ber) pathway [1].

References

[1]. madhusudan s, smart f, shrimpton p, et al. isolation of a small molecule inhibitor of dna base excision repair. nucleic acids res, 2005, 33(15): 4711-4724.

Properties of 7-Nitroindole-2-carboxylic acid

Melting point: 260-261 °C
Boiling point: 344.99°C (rough estimate)
Density  1.4588 (rough estimate)
refractive index  1.5570 (estimate)
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  DMSO: >20mg/mL
form  Tan solid
pka 4.03±0.30(Predicted)
color  Light yellow to yellow
Water Solubility  Insoluble
CAS DataBase Reference 6960-45-8(CAS DataBase Reference)
EPA Substance Registry System 1H-Indole-2-carboxylic acid, 7-nitro- (6960-45-8)

Safety information for 7-Nitroindole-2-carboxylic acid

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H319:Serious eye damage/eye irritation
H334:Sensitisation, respiratory
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Computed Descriptors for 7-Nitroindole-2-carboxylic acid

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