7-Nitroindole-2-carboxylic acid
Synonym(s):7-Nitro-1H-indole-2-carboxylic acid;7-Nitroindole-2carboxylic acid;7-Nitroindole-2-carboxylic acid, CRT0044876;DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem;NSC 69877
- CAS NO.:6960-45-8
- Empirical Formula: C9H6N2O4
- Molecular Weight: 206.15
- MDL number: MFCD00044720
- EINECS: 230-154-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 21:40:10
What is 7-Nitroindole-2-carboxylic acid?
Chemical properties
brown powder
The Uses of 7-Nitroindole-2-carboxylic acid
7-Nitro-1H-indole-2-carboxylic Acid is a potent and selective APE1 inhibitor, which at low micromolar concentrations inhibits the AP endonuclease, 3''-phosphodiesterase and 3''-phosphatase activities of APE1 .
What are the applications of Application
DNA Base Excision Repair Pathway Inhibitor is a potent, nontoxic, and cell-permeable APE1 inhibitor
Biological Activity
crt0044876 is a potent and selective inhibitor of ape1 with ic50 value of 3.06 μm [1].apurinic/apyrimidinic endonuclease-1 (ape1) is a member of the highly conserved exonucleaseiii family of ap endonucleases and plays an important role in dna repair. ape1 exhibits 3’-phosphodiesterase activity and weak 3’-phosphatase activity, 3’-5’-exonuclease activity and rnaseh activity [1].crt0044876 is a potent and selective ape1 inhibitor. in hela whole cell extract, crt0044876 inhibited apurinic/apyrimidinic (ap) site cleavage catalyzed by ape1. crt0044876 inhibited both the ap endonuclease and exonuclease activities of exonuclease iii, the bacterial homologue of ape1. crt0044876 inhibited the 3’-phosphoglycolate diesterase activity of ape1 with ic50 value of 5 μm and also inhibited 3’-phosphatase activity through binding to dna repair active site of ape1. in ht1080 fibrosarcoma cells, crt0044876 significantly increased ap site accumulation and was non-toxic at concentrations up to 400 μm. also, crt0044876 potentiated the cytotoxicity induced by alkylating agent mms, temozolomide, hydrogen peroxide and hmdurd through specific inhibition of the base excision repair (ber) pathway [1].
References
[1]. madhusudan s, smart f, shrimpton p, et al. isolation of a small molecule inhibitor of dna base excision repair. nucleic acids res, 2005, 33(15): 4711-4724.
Properties of 7-Nitroindole-2-carboxylic acid
Melting point: | 260-261 °C |
Boiling point: | 344.99°C (rough estimate) |
Density | 1.4588 (rough estimate) |
refractive index | 1.5570 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | DMSO: >20mg/mL |
form | Tan solid |
pka | 4.03±0.30(Predicted) |
color | Light yellow to yellow |
Water Solubility | Insoluble |
CAS DataBase Reference | 6960-45-8(CAS DataBase Reference) |
EPA Substance Registry System | 1H-Indole-2-carboxylic acid, 7-nitro- (6960-45-8) |
Safety information for 7-Nitroindole-2-carboxylic acid
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
Computed Descriptors for 7-Nitroindole-2-carboxylic acid
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