7-Hydroxycoumarin
Synonym(s):7-Hydroxy-2H-1-benzopyran-2-one;7-Hydroxycoumarin
- CAS NO.：93-35-6
- Empirical Formula: C9H6O3
- Molecular Weight: 162.14
- MDL number: MFCD00006878
- EINECS: 202-240-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:07:02
What is 7-Hydroxycoumarin?
Chemical properties
Light Brownish Powder
The Uses of 7-Hydroxycoumarin
A metabolite of Coumarin. The aglucon of skimmin. Present in many plants
The Uses of 7-Hydroxycoumarin
antifungal, phytoalexin
The Uses of 7-Hydroxycoumarin
7-Hydroxycoumarin is used as an intracellular pH sensitive fluorescent indicator & bloodbrain barrier probe. It is used as a sunscreen agent, and an optical brightener for textiles. It has also been used as a gain medium for dye lasers.
The Uses of 7-Hydroxycoumarin
In sunscreen lotions and creams; as intracellular and pH sensitive fluorescent indicator and blood-brain barrier probe.
What are the applications of Application
Umbelliferone is an intracellular pH sensitive fluorescent indicator & bloodbrain barrier probe
Definition
ChEBI: A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.
General Description
Umbelliferone is a naturally occurring coumarin, present in a variety of medicinal plants from the Apiaceae (Umbelliferae) family and also in plants from other families such as mouse-ear hawkweed.
Purification Methods
It crystallises from water (m 232-232.2o) or EtOH (m 232o). It sublimes at 160o/0.001mm. Fluorescence: Em max 452nm/Exc 325nm in 50% EtOH. [Beilstein 18 H 27, 18 I 306, 18 II 16, 18 III/IV 294, 18/1 V 386.]
Properties of 7-Hydroxycoumarin
| Melting point: | 230 °C (dec.)(lit.) |
| Boiling point: | 248.82°C (rough estimate) |
| Density | 1.2599 (rough estimate) |
| refractive index | 1.5380 (estimate) |
| storage temp. | 2-8°C |
| solubility | dioxane: soluble |
| form | Powder and Agglomerate |
| pka | 7.11(at 25℃) |
| color | Off-white to beige-brownish |
| PH Range | Non/ uorescence (6.5) to blue / uorescence (8.0) |
| Odor | develops odor of coumarin on heating |
| Water Solubility | 1 g/100 mL (100 ºC) |
| λmax | 320nm |
| Merck | 14,9847 |
| BRN | 127683 |
| Major Application | Fluorescent brighteners, fungicides, cosmetics, antitrypanosomal, antileishmanial activities, antifungal, antibacterial, antiinflammatory, antiHIV, detection of microorganisms, treatment of impaired neurotransmission disorders, Alzheimer’s disease, vascular and lymphatic edema cancer, early diagnosis of stroke, dental material, drug-coated coronary stent system |
| CAS DataBase Reference | 93-35-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 7-Hydroxycoumarin(93-35-6) |
| EPA Substance Registry System | Umbelliferone (93-35-6) |
Safety information for 7-Hydroxycoumarin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 7-Hydroxycoumarin
| InChIKey | ORHBXUUXSCNDEV-UHFFFAOYSA-N |
7-Hydroxycoumarin manufacturer
JSK Chemicals
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Phone:+919879767970
Whatsapp: +91 9879767970
product: 93-35-6 7-Hydroxycoumarin, 98% (Custom
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