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HomeProduct name list7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

Synonym(s):7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol;7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol

  • CAS NO.:440122-66-7
  • Empirical Formula: C13H8BrNO3
  • Molecular Weight: 306.11
  • MDL number: MFCD16618385
  • EINECS: 604-604-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol Structural

What is 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol?

The Uses of 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

WAY 200070 is an aryl diphenolic azole and a selective ERβ agonist. This compound is suitable for estrogen receptor signaling research.

What are the applications of Application

WAY 200070 is a selective ERβ agonist

Biological Activity

WAY-200070 is a selective estrogen receptor agonist with IC50 of 2.3 nM.

in vivo

Administration of WAY-200070 (30 mg/kg sc) causes nuclear translocation of ERRβ receptors in WT mice. Administration of it produces a delayed 50% increase in dopamine in the striatum of wild type mice. It reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070 , shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.

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Properties of 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

Boiling point: 463.6±35.0 °C(Predicted)
Density  1.720±0.06 g/cm3(Predicted)
storage temp.  Store at RT
solubility  DMSO: ≥20mg/mL
form  solid
pka 7.26±0.40(Predicted)
color  White to off-white

Safety information for 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

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