7-(2-HYDROXYETHYL)THEOPHYLLINE

Chemical properties

White Solid

Originator

Duolip,Merckle,W. Germany,1981

The Uses of 7-(2-HYDROXYETHYL)THEOPHYLLINE

An inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities.

The Uses of 7-(2-HYDROXYETHYL)THEOPHYLLINE

Cardiac analeptic;Phosphodiesterase inhibitor

The Uses of 7-(2-HYDROXYETHYL)THEOPHYLLINE

Useful synthetic intermediate in the preparation of 7-substituted xanthines.

Definition

ChEBI: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione is an oxopurine.

What are the applications of Application

7-(β-Hydroxyethyl)-theophylline is a weak phosphodiesterase inhibitor & an intermediate for 7-substituted xanthine

Manufacturing Process

107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.

Therapeutic Function

Antihyperlipidemic

Biochem/physiol Actions

Pharmacological profile similar to theophylline.