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HomeProduct name list7-(2-HYDROXYETHYL)THEOPHYLLINE

7-(2-HYDROXYETHYL)THEOPHYLLINE

Synonym(s):1,3-Dimethyl-7-(2-hydroxyethyl)xanthine;7-(β-Hydroxyethyl)theophylline

  • CAS NO.:519-37-9
  • Empirical Formula: C9H12N4O3
  • Molecular Weight: 224.22
  • MDL number: MFCD00055055
  • EINECS: 208-269-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
7-(2-HYDROXYETHYL)THEOPHYLLINE Structural

What is 7-(2-HYDROXYETHYL)THEOPHYLLINE?

Chemical properties

White Solid

Originator

Duolip,Merckle,W. Germany,1981

The Uses of 7-(2-HYDROXYETHYL)THEOPHYLLINE

An inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities.

The Uses of 7-(2-HYDROXYETHYL)THEOPHYLLINE

Cardiac analeptic;Phosphodiesterase inhibitor

The Uses of 7-(2-HYDROXYETHYL)THEOPHYLLINE

Useful synthetic intermediate in the preparation of 7-substituted xanthines.

What are the applications of Application

7-(β-Hydroxyethyl)-theophylline is a weak phosphodiesterase inhibitor & an intermediate for 7-substituted xanthine

Definition

ChEBI: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione is an oxopurine.

Manufacturing Process

107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.

Therapeutic Function

Antihyperlipidemic

Biochem/physiol Actions

Pharmacological profile similar to theophylline.

Properties of 7-(2-HYDROXYETHYL)THEOPHYLLINE

Melting point: 163°C
Boiling point: 365.61°C (rough estimate)
Density  1.3055 (rough estimate)
refractive index  1.6300 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  H2O: Solutions may be stored for several days at 4°C.soluble
pka 14.48±0.10(Predicted)
form  solid
color  white
Water Solubility  2.991g/L(temperature not stated)
Merck  14,3878
CAS DataBase Reference 519-37-9(CAS DataBase Reference)

Safety information for 7-(2-HYDROXYETHYL)THEOPHYLLINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for 7-(2-HYDROXYETHYL)THEOPHYLLINE

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