7-(2-HYDROXYETHYL)THEOPHYLLINE
Synonym(s):1,3-Dimethyl-7-(2-hydroxyethyl)xanthine;7-(β-Hydroxyethyl)theophylline
- CAS NO.:519-37-9
- Empirical Formula: C9H12N4O3
- Molecular Weight: 224.22
- MDL number: MFCD00055055
- EINECS: 208-269-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is 7-(2-HYDROXYETHYL)THEOPHYLLINE?
Chemical properties
White Solid
Originator
Duolip,Merckle,W. Germany,1981
The Uses of 7-(2-HYDROXYETHYL)THEOPHYLLINE
An inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities.
The Uses of 7-(2-HYDROXYETHYL)THEOPHYLLINE
Cardiac analeptic;Phosphodiesterase inhibitor
The Uses of 7-(2-HYDROXYETHYL)THEOPHYLLINE
Useful synthetic intermediate in the preparation of 7-substituted xanthines.
What are the applications of Application
7-(β-Hydroxyethyl)-theophylline is a weak phosphodiesterase inhibitor & an intermediate for 7-substituted xanthine
Definition
ChEBI: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione is an oxopurine.
Manufacturing Process
107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol)
7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They
were heated together for 15 hours in a water separator following the addition
of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute
sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated
in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55%
yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The
compound had a melting point of 131°C to 132°C.
Therapeutic Function
Antihyperlipidemic
Biochem/physiol Actions
Pharmacological profile similar to theophylline.
Properties of 7-(2-HYDROXYETHYL)THEOPHYLLINE
Melting point: | 163°C |
Boiling point: | 365.61°C (rough estimate) |
Density | 1.3055 (rough estimate) |
refractive index | 1.6300 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | H2O: Solutions may be stored for several days at 4°C.soluble |
pka | 14.48±0.10(Predicted) |
form | solid |
color | white |
Water Solubility | 2.991g/L(temperature not stated) |
Merck | 14,3878 |
CAS DataBase Reference | 519-37-9(CAS DataBase Reference) |
Safety information for 7-(2-HYDROXYETHYL)THEOPHYLLINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for 7-(2-HYDROXYETHYL)THEOPHYLLINE
Abamectin manufacturer
Kores India Limited (Kores Pharmaceuticals And Chemicals)
Orgamine Chemicals(I) Pvt Ltd
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