Methylprednisolone hemisuccinate

Synonym(s):11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-succinate;Methylprednisolone hemisuccinate;Methylprednisolone hydrogen succinate

CAS NO.：2921-57-5
Empirical Formula: C26H34O8
Molecular Weight: 474.54
MDL number: MFCD00271782
EINECS: 220-863-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 21:39:59

Methylprednisolone hemisuccinate Structural

What is Methylprednisolone hemisuccinate?

Chemical properties

White or almost white, hygroscopic powder.

The Uses of Methylprednisolone hemisuccinate

Glucocorticoid.

The Uses of Methylprednisolone hemisuccinate

6α-Methylprednisolone 21-Hemisuccinate is a derivative of methylprednisolone (M325934), a glucocorticoid and a anti-inflammatory drug used to treat central nervous system disorders such as multiple sclerosis. 6α-Methylprednisolone 21-Hemisuccinate was examined for potential therapeutic efficacy in a model of neuroinflammation in rats with acute autoimmune encephalomyelitis.

Background

A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.

Definition

ChEBI: Methylprednisolone succinate is a corticosteroid hormone and a hemisuccinate.

brand name

A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).

Pharmacokinetics

Methylprednisolone sodium succinate (the sodium salt of methylprednisolone hemisuccinate) has the same metabolic and anti-inflammatory actions as methylprednisolone. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity.

Metabolism

Not Available

Properties of Methylprednisolone hemisuccinate

Melting point:	>230°C (dec.)
Boiling point:	689.6±55.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Practically insoluble in water, slightly soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
form	neat
pka	4.29±0.17(Predicted)
form	Solid
color	White to Off-White
CAS DataBase Reference	2921-57-5(CAS DataBase Reference)

Safety information for Methylprednisolone hemisuccinate

Signal word	Danger
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..…