Methylprednisolone hemisuccinate
Synonym(s):11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-succinate;Methylprednisolone hemisuccinate;Methylprednisolone hydrogen succinate
- CAS NO.：2921-57-5
- Empirical Formula: C26H34O8
- Molecular Weight: 474.54
- MDL number: MFCD00271782
- EINECS: 220-863-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is Methylprednisolone hemisuccinate?
Chemical properties
White or almost white, hygroscopic powder.
The Uses of Methylprednisolone hemisuccinate
Glucocorticoid.
The Uses of Methylprednisolone hemisuccinate
6α-Methylprednisolone 21-Hemisuccinate is a derivative of methylprednisolone (M325934), a glucocorticoid and a anti-inflammatory drug used to treat central nervous system disorders such as multiple sclerosis. 6α-Methylprednisolone 21-Hemisuccinate was examined for potential therapeutic efficacy in a model of neuroinflammation in rats with acute autoimmune encephalomyelitis.
Background
A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.
Definition
ChEBI: Methylprednisolone succinate is a corticosteroid hormone and a hemisuccinate.
brand name
A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).
Pharmacokinetics
Methylprednisolone sodium succinate (the sodium salt of methylprednisolone hemisuccinate) has the same metabolic and anti-inflammatory actions as methylprednisolone. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity.
Metabolism
Not Available
Properties of Methylprednisolone hemisuccinate
| Melting point: | >230°C (dec.) |
| Boiling point: | 689.6±55.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, slightly soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides. |
| form | neat |
| pka | 4.29±0.17(Predicted) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 2921-57-5(CAS DataBase Reference) |
Safety information for Methylprednisolone hemisuccinate
| Signal word | Danger |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Methylprednisolone hemisuccinate
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