6,9-Dichloro-2-methoxyacridine

CAS NO.：86-38-4
Empirical Formula: C14H9Cl2NO
Molecular Weight: 278.13
MDL number: MFCD00005028
EINECS: 201-666-7
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 6,9-Dichloro-2-methoxyacridine?

The Uses of 6,9-Dichloro-2-methoxyacridine

6,9-Dichloro-2-methoxyacridine is used to prepare 6-chloro-2-methoxy-acridin-9-ylamine by reacting with phenol and ammonium carbonate. It is used in the preparation of 9-amino-6-chloro-2-methoxyacridine, N'-(6-Chloro-2-methoxy-acridin-9-yl)-heptylamine and N,N'-bis-(6-chloro-2-methoxy-acridin-9-yl)-hexane-1,6-diamine. Further, it is involved in the preparation of 4-aminoquinoline and 9-aminoacridine derivatives by reaction with quinolizidinylalkylamines.

General Description

6,9-Dichloro-2-methoxyacridine on reaction with quinolizidinylalkylamines yields 4-aminoquinoline and 9-aminoacridine derivatives.

Purification Methods

Crystallise it from *benzene or 1,2-dichloroethane (m 162-163o). [Hall & Turner J Chem Soc 697 1945, Beilstein 21 III/IV 1553.]

Properties of 6,9-Dichloro-2-methoxyacridine

Melting point:	163-165 °C (lit.)
Boiling point:	444.3±25.0 °C(Predicted)
Density	1.52 g/cm3
storage temp.	2-8°C
pka	2.98±0.10(Predicted)
Water Solubility	Insoluble in water.
BRN	226309
CAS DataBase Reference	86-38-4(CAS DataBase Reference)

Safety information for 6,9-Dichloro-2-methoxyacridine

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.