4-Chloroquinoline

CAS NO.：611-35-8
Empirical Formula: C9H6ClN
Molecular Weight: 163.6
MDL number: MFCD00006773
EINECS: 210-267-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 4-Chloroquinoline?

Chemical properties

Pale yellow low melting solid

The Uses of 4-Chloroquinoline

4-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Purification Methods

Possible impurities include the 2-isomer. It is best purified by converting to the picrate (m 212-213o dec) in EtOH and recrystallising it from EtOH (where the picrate of the 2-chloroquinoline remains in solution) or EtOAc . The picrate is decomposed with 5% aqueous NaOH, extracted in CHCl3, washed with H2O, dried (MgSO4), evaporated and distilled in a vacuum. It can be steam distilled from slightly alkaline aqueous solutions, the aqueous distillate is extracted with Et2O, evaporated and distilled. The distillate solidifies on cooling. [Bobránski Chem Ber 71 578 1938, Beilstein 20/7 V 314.]

Properties of 4-Chloroquinoline

Melting point:	28-31 °C (lit.)
Boiling point:	260-261 °C (lit.)
Density	1.25 g/mL at 20 °C (lit.)
refractive index	1.6110 (estimate)
Flash point:	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to lump
pka	3.57±0.13(Predicted)
color	White to Almost white
Water Solubility	Partly soluble in water.
λmax	316nm(EtOH aq.)(lit.)
BRN	114721
CAS DataBase Reference	611-35-8(CAS DataBase Reference)
NIST Chemistry Reference	4-Chloroquinoline(611-35-8)

Safety information for 4-Chloroquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.