6-hydroxydexamethasone
- CAS NO.：55879-47-5
- Empirical Formula: C22H29FO6
- Molecular Weight: 408.46
- Update Date: 2024-10-23 13:36:13
What is 6-hydroxydexamethasone?
Description
6β-hydroxy Dexamethasone is a metabolite of dexamethasone (Item Nos. 11015 | 20340) that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans. The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.
Chemical properties
Off-White Solid
The Uses of 6-hydroxydexamethasone
The hydrophilic metabolite of Dexamethasone (D298800).
What are the applications of Application
6β-Hydroxy Dexamethasone is a hydrophilic metabolite of Dexamethasone
Properties of 6-hydroxydexamethasone
| Melting point: | 259-262°C |
| Boiling point: | 613.2±55.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Dioxane (Very Slightly, Sonicated), Methanol (Slightly) |
| form | Solid |
| pka | 12.06±0.70(Predicted) |
| color | White to Light Yellow |
Safety information for 6-hydroxydexamethasone
Computed Descriptors for 6-hydroxydexamethasone
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