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HomeProduct name list6-Hydroxycoumarin

6-Hydroxycoumarin

6-Hydroxycoumarin Structural

What is 6-Hydroxycoumarin?

Description

6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity.

Occurrence

6-Hydroxycoumarin is a natural product found in Grevillea robusta and Amburana cearensis with data available.

The Uses of 6-Hydroxycoumarin

6-Hydroxycoumarin (cas# 6093-68-1) is a compound useful in organic synthesis.

Preparation

(1) synthesis of 6-aminocoumarins:In polar solvent, using 6- nitroscumarin as raw material, using hydrazine hydrate as hydrogen Source, is reducing catalyst using ferric chloride (FeCl36H2O), at ambient pressure reduces 6-nitroscumarin, prepare 6- aminocoumarins;
(2) synthesis of 6-Hydroxycoumarins:In sulfuric acid solution, one-step method is by 6-aminocoumarins after diazo-reaction Direct hydrolysis, prepares 6-Hydroxycoumarins in high yield.
The preparation method of 6 Hydroxycoumarins

Properties of 6-Hydroxycoumarin

Melting point: 249-253 °C (lit.)
Boiling point: 248.82°C (rough estimate)
Density  1.2500
refractive index  1.5380 (estimate)
storage temp.  Sealed in dry,Room Temperature
pka 8.92±0.20(Predicted)
form  Solid
color  White to yellow
λmax 349nm(EtOH)(lit.)
CAS DataBase Reference 6093-68-1(CAS DataBase Reference)

Safety information for 6-Hydroxycoumarin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 6-Hydroxycoumarin

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