6-Hydroxycoumarin

CAS NO.：6093-68-1
Empirical Formula: C9H6O3
Molecular Weight: 162.14
MDL number: MFCD00630040
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 6-Hydroxycoumarin?

Description

6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity.

Occurrence

6-Hydroxycoumarin is a natural product found in Grevillea robusta and Amburana cearensis with data available.

The Uses of 6-Hydroxycoumarin

6-Hydroxycoumarin (cas# 6093-68-1) is a compound useful in organic synthesis.

Preparation

(1) synthesis of 6-aminocoumarins：In polar solvent, using 6- nitroscumarin as raw material, using hydrazine hydrate as hydrogen Source, is reducing catalyst using ferric chloride (FeCl36H2O), at ambient pressure reduces 6-nitroscumarin, prepare 6- aminocoumarins；
(2) synthesis of 6-Hydroxycoumarins：In sulfuric acid solution, one-step method is by 6-aminocoumarins after diazo-reaction Direct hydrolysis, prepares 6-Hydroxycoumarins in high yield.
The preparation method of 6 Hydroxycoumarins

Properties of 6-Hydroxycoumarin

Melting point:	249-253 °C (lit.)
Boiling point:	248.82°C (rough estimate)
Density	1.2500
refractive index	1.5380 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	8.92±0.20(Predicted)
form	Solid
color	White to yellow
λmax	349nm(EtOH)(lit.)
CAS DataBase Reference	6093-68-1(CAS DataBase Reference)

Safety information for 6-Hydroxycoumarin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.