6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
Synonym(s):6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine hydrochloride;6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride;HOE-36801 hydrochloride
- CAS NO.：56776-32-0
- Empirical Formula: C17H18Cl2N2O
- Molecular Weight: 337.24362
- MDL number: MFCD18086857
- EINECS: 260-380-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride?
Chemical properties
Low Melting White Solid
The Uses of 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
Psychotropic agent with anxiolytic and anticonvulsant activity.
The Uses of 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
Etifoxine hydrochloride has been used as a γ-aminobutyric acid (GABA)-receptor agonist to study its effects on insulin expression in α cell line (αTC1)
What are the applications of Application
Etifoxine Hydrochloride is an allosteric GABAA receptor modulator
Biochem/physiol Actions
Etifoxine is an anxiolytic anticonvulsant, which promotes axonal regeneration. It binds to β2 and β3 subunits of the GABAA receptor complex, a different target site to benzodiazepines, and binds to the translocator protein (18 kDa) TSPO, formerly known as the peripheral or mitochondrial benzodiazepine receptor. TSPO carries cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step of steroidogenesis. Whereas, its anxiolytic effects involve GABAA receptors and TSPO, etifoxine′s neuroregenerative effects mainly involve TSPO.
storage
Store at +4°C
Properties of 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
| Melting point: | ND |
| storage temp. | -20°C |
| solubility | DMSO: ≥5mg/mL |
| form | powder |
| color | white to beige |
| Stability: | Hygroscopic |
Safety information for 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
Computed Descriptors for 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
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