6-AZAURIDINE
Synonym(s):2-β-D -Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione;6-Azauracil riboside
- CAS NO.:54-25-1
- Empirical Formula: C8H11N3O6
- Molecular Weight: 245.19
- MDL number: MFCD00006472
- EINECS: 200-199-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is 6-AZAURIDINE?
Chemical properties
White powder
The Uses of 6-AZAURIDINE
6-Azauridine can be applied in antiviral studies. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. It is also used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
The Uses of 6-AZAURIDINE
Research on cell formation and cancer.
The Uses of 6-AZAURIDINE
6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP and it is used in antiviral studies.
What are the applications of Application
6-Azauridine is can be applied in antiviral studies
Definition
ChEBI: 6-azauridine is a N-glycosyl-1,2,4-triazine. It has a role as an antineoplastic agent, an antimetabolite and a drug metabolite.
General Description
6-Azauridine is a pyrimidine nucleoside analog.
Biochem/physiol Actions
6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites.
Properties of 6-AZAURIDINE
Melting point: | 157-159 °C(lit.) |
Boiling point: | 388.15°C (rough estimate) |
Density | 1.4866 (rough estimate) |
refractive index | 1.7950 (estimate) |
storage temp. | 2-8°C |
solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated), Pyridine (Slightly), Water |
form | Powder |
pka | 6.70(at 25℃) |
color | White |
Water Solubility | It is soluble in water. |
Merck | 14,904 |
Stability: | Hygroscopic |
CAS DataBase Reference | 54-25-1(CAS DataBase Reference) |
Safety information for 6-AZAURIDINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H351:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for 6-AZAURIDINE
InChIKey | WYXSYVWAUAUWLD-YGWZKZRUSA-N |
New Products
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