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HomeProduct name list3-Methylamino-1,2-propanediol

3-Methylamino-1,2-propanediol

  • CAS NO.:40137-22-2
  • Empirical Formula: C4H11NO2
  • Molecular Weight: 105.14
  • MDL number: MFCD00082732
  • EINECS: 254-809-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
3-Methylamino-1,2-propanediol Structural

What is 3-Methylamino-1,2-propanediol?

Description

3-Methylamino-1,2-propanediol (MAPD) is a clear liquid with the chemical formula C4H11NO2. It can be synthesized from allylamine and alkanolamine via a thermal process. It reacts with chloride to form methyl chloroacetate, which can then be converted into 3-methylamino-1,2-propanediol by reaction with methanol. The production process for this substance has been shown to generate low levels of hazardous substances such as polycyclic aromatic hydrocarbons (PAHs) and dioxins.

Chemical properties

clear colorless to pale yellow viscous liquid

The Uses of 3-Methylamino-1,2-propanediol

3-Methylamino-1,2-propanediol is a reactive compound that is used in the synthesis of organic acids. It is also used as an intermediate in the manufacture of polyethylene glycols and particle coatings.

Definition

ChEBI: 3-methylamino-1,2-propanediol is a secondary amine.

Preparation

3-Methylamino-1,2-propanediol (MAPD) is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with monomethyl amine in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps.  
3-Methylamino-1,2-propanediol
N-Methyl-1-amino-2,3-propandiol (45A) Methylamine (172ml of a 40% solution in water, 2 mol) was cooled to 0 °C and 2,3-epoxy-1-propanol (25g, 0.34mol) was added at a rate to maintain the temperature at or below 10 °C. The mixture was stirred for 3 hours at 0 °C. Excess methylamine and water was evaporated in vacuo and the product was purified by distillation at 103-105 °C, at 0.5 mm Hg, to give the compound 3-Methylamino-1,2-propanediol.
3-Methylamino-1,2-propanediol

Hazard

3-Methylamino-1,2-propanediol is danger.
H314 (32.76%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H315 (67.24%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (65.52%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Properties of 3-Methylamino-1,2-propanediol

Melting point: 69°C (estimate)
Boiling point: 247 °C
Density  1.095 g/mL at 20 °C(lit.)
refractive index  n20/D 1.476
Flash point: 152 °C
storage temp.  Inert atmosphere,Room Temperature
form  clear liquid
pka 14.09±0.20(Predicted)
Specific Gravity 1.0921
color  Colorless to Almost colorless
PH 11.5 (100g/l, H2O, 20℃)
Water Solubility  miscible
BRN  1733341
CAS DataBase Reference 40137-22-2(CAS DataBase Reference)

Safety information for 3-Methylamino-1,2-propanediol

Signal word Warning
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H314:Skin corrosion/irritation
H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 3-Methylamino-1,2-propanediol

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